research The cellular basis of mechanosensory Merkel-cell innervation during development
BMP signaling is essential for the development of touch domes.
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510-540 / 884 resultsresearch Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament
Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.
research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer
TGM3 is important for skin and hair structure and may help diagnose cancer.
research Wanted, dead and alive: Why a multidisciplinary approach is needed to unlock hair treatment potential
Different fields of expertise must work together to better understand hair growth and create effective hair loss treatments.
research Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment
WNT activation in scalp fibroblasts boosts hair growth by increasing FGF9.
research Integrated miRNA-mRNA analysis reveals regulatory pathways underlying the curly fleece trait in Chinese tan sheep
Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.
research SFRP2 augments Wnt/β-catenin signalling in cultured dermal papilla cells
SFRP2 boosts Wnt3a/β-catenin signals in hair growth cells, with stronger effects in beard cells than scalp cells.
research Skin Development and Disease: A Molecular Perspective
Understanding molecular processes in skin development is key to creating targeted treatments for skin disorders.
research Lymphotoxin-β regulates periderm differentiation during embryonic skin development
Lymphotoxin-β is crucial for proper skin development in embryos.
research Integrated Lipidomics in the Secreted Phospholipase A2 Biology
Different sPLA2 enzymes have unique roles in phospholipid metabolism and biological processes.
research Transcriptome meta-analysis reveals the hair genetic rules in six animal breeds and genes associated with wool fineness
Different sheep breeds share similar genetic factors affecting wool fineness.
research Biofabrication of Human Skin with Its Appendages
Current methods can't fully recreate skin and its features, and more research is needed for clinical use.
research Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis
Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.
research The origins of skin diversity: lessons from dermal fibroblasts
New research shows that skin diversity is influenced by different types of dermal fibroblasts and their development, especially involving the Wnt/β-catenin pathway.
research STAT3 Partly Inhibits Cell Proliferation via Direct Negative Regulation of FST Gene Expression
The protein STAT3 slows down cell growth by blocking the FST gene, which affects hair development in sheep.
research Phenotyping mice with skin, hair, or nail abnormalities: A systematic approach and methodologies from simple to complex
Understanding genetic variations in mice is crucial for studying skin, hair, or nail abnormalities.
research Bazi Bushen capsule alleviates skin photoaging by targeting the KEAP1–NRF2 pathway
Bazi Bushen capsules reduce skin aging and damage from UV rays.
research The Retinoic-Acid-Related Orphan Receptor Alpha May Be Highly Involved in the Regulation of Seasonal Hair Molting
RORA plays a key role in controlling seasonal hair molting by affecting hair follicle cell activity.
research Evolution of long scalp hair in humans
Long scalp hair evolved for cooling and social signaling.
research AP collagen peptides (APCPs ) promote hair growth by activating the GSK ‐3β/β‐catenin pathway and improve hair condition
AP collagen peptides help hair grow and improve hair health.
research Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition
Enzymes involved in Vitamin A metabolism affect hair growth and type in mice.
research SP1 and KROX20 Regulate the Proliferation of Dermal Papilla Cells and Target the CUX1 Gene
SP1 promotes and KROX20 inhibits hair cell growth by affecting the CUX1 gene.
research Development of Woolly Hair and Hairlessness in a CRISPR−Engineered Mutant Mouse Model with KRT71 Mutations
Researchers made a mouse model with curly hair and hair loss by editing a gene.
research Proceedings of the Ninth World Congress for Hair Research (2015)
The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.
research Hair Sciences: The hair cycle discussed with Dr. Gilliam Westgate
Androgens affect hair growth and shedding, with genetic and non-genetic factors influencing baldness.
research A “hair‐raising” history of alopecia areata
The document concludes that understanding and treatments for alopecia areata have significantly advanced, now recognizing it as an autoimmune disorder.
research AB1159 HIGH FAT DIET AND THE ADIPOCYTE TO MYOFIBROBLAST TRANSITION: IMPLICATIONS FOR SYSTEMIC SCLEROSIS CUTANEOUS FIBROSIS
A high fat lard diet may protect against skin fibrosis and affect hair growth.
research Uso da deslorelina na castração química de cães e sua aplicabilidade para o tratamento da alopecia X em Spitz Alemão: relato de caso
Deslorelin can help control reproduction and improve hair growth in German Spitz dogs.
research Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol-Analogs
Topical calcitriol-analogs can reduce hair loss caused by chemotherapy.
research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression
HOXC13 is crucial for regulating hair keratin genes in hair follicles.