186 citations
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February 1980 in “Clinical Endocrinology” During puberty, hormone levels rise, with early increases in some steroids and most menstrual cycles becoming regular by six years after menarche.
September 2023 in “The Journal of clinical endocrinology and metabolism” Genetic risk for PCOS can affect children's growth, metabolism, and development from early life into adulthood.
2 citations
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July 2008 in “Paediatrics & child health” Severe acne in a young girl may indicate underlying hormonal issues.
February 2024 in “Pediatrics in review” A 15-year-old girl with missed periods was diagnosed with a pituitary disorder and treated with hormones and steroids.
A rare skin condition in a 17-year-old was diagnosed late, stressing the need for careful evaluation and genetic testing.
12 citations
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January 2005 in “Pediatric Dermatology” Fox Fordyce disease might be more common in prepubertal girls than thought and can be managed with treatment.
July 2024 in “Reproductive health of woman” Girls conceived via assisted reproductive technologies show early puberty signs and larger ovaries.
April 1974 in “Pediatric Research” 13 citations
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December 2009 in “Journal of the Peripheral Nervous System” TRPA1 and TRPV1 channels don't affect mechanotransduction in rat sinus hair follicles.
6 citations
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November 2017 in “Journal of the Peripheral Nervous System” Mercury exposure damages small nerve fibers in rats' skin.
29 citations
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February 2019 in “Environment international” Higher early lead exposure is linked to delayed puberty in girls.
November 2024 in “Jurnal Biomedika dan Kesehatan” Premature graying in young children can affect self-esteem, and addressing underlying health issues may reverse it.
April 2020 in “Journal of the Endocrine Society” Early diagnosis of PSIS can lead to normal height with growth hormone and testosterone treatment.
19 citations
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March 2004 in “The Journal of Clinical Endocrinology & Metabolism” Testosterone and letrozole treatment speeds up puberty in boys with delayed development.
2 citations
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April 2021 in “PLoS ONE” Rural Bangladeshi girls mature later than peers in other low and middle-income countries due to poor nutrition and socioeconomic conditions.
5 citations
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May 2023 in “Science of the total environment” PFAS exposure in adolescence may delay puberty in females.
July 2020 in “Endocrine practice” A 13-year-old boy with Cushing syndrome has high cortisol levels from a pituitary gland issue and underdeveloped sexual characteristics.
November 2022 in “Journal of the Endocrine Society” A 13-year-old girl's masculine symptoms improved after surgery for a rare adrenal tumor that produced male hormones.
10 citations
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September 2007 in “Pediatrics in Review” Gynecomastia and premature thelarche often resolve naturally but need evaluation to rule out serious issues.
17 citations
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October 2006 in “Molecular and Cellular Endocrinology” The L457(3.43)R mutation in the human lutropin receptor causes increased activity and hormone insensitivity, leading to precocious puberty.
12 citations
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March 2015 in “Pediatric Dermatology” Early diagnosis and treatment of PCOS in young people is important to prevent long-term health problems.
August 2022 in “International journal of reproduction, contraception, obstetrics and gynecology” The study found that 7.21% of young girls have polycystic ovarian syndrome, with symptoms like irregular periods, abnormal hair growth, and acne. Early diagnosis is important to prevent long-term complications.
3 citations
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June 2017 in “Deep Blue (University of Michigan)” Early exposure to fluoride, lead, and certain nutrients affects puberty differently in boys and girls.
17 citations
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February 2014 in “Pediatric Research” 7 citations
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June 2006 in “Pediatrics in Review” Most genital symptoms in prepubertal girls are normal or nontraumatic, not signs of abuse.
10 citations
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February 2007 in “Current Opinion in Endocrinology, Diabetes and Obesity” Low birthweight and rapid weight gain after birth may increase the risk of developing polycystic ovary syndrome.
December 1981 in “Pediatric Research”
October 2024 in “Journal of the Endocrine Society” Hirsutism in young girls can have causes other than PCOS, so diagnoses should be reassessed if treatments don't work.
124 citations
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June 2002 in “Best Practice & Research Clinical Endocrinology & Metabolism” Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.
October 2024 in “Journal of the Endocrine Society” Hirsutism in young girls can have various causes beyond PCOS, so diagnoses should be reconsidered if treatments don't work.