research A Phase 1 Study to Investigate the Effects of Cortexolone 17α‐Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity
Clascoterone is safe for the heart, even at high doses.
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research ApoBDs: a paradigm shift from cellular debris to therapeutic vehicles
ApoBDs, once seen as waste, are now viewed as potential tools for disease treatment and tissue repair.
research Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review
Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.
research Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery
Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.
research Liposomes in dermatology today
Liposomes improve drug delivery and reduce skin irritation in dermatology.
research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
research Incorporation of Isotopically Labeled Cocaine and Metabolites into Human Hair: 1. Dose-Response Relationships
Hair analysis can detect cocaine use but doesn't accurately show the amount or timing of use.
research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research
New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.
research Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer
PLD is an effective and safer alternative for treating breast cancer.
research Dermatologic Manifestations of Polycystic Ovary Syndrome
Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.
research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne
Anti-acne medications may work by reducing the activity of a protein involved in acne development.
research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures
EETs can delay seizures by affecting GABA activity, offering potential new treatments for seizures.
research Mitoxantrone
Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.
research Dutasteride
Dutasteride effectively treats enlarged prostate, reduces prostate cancer risk, and promotes hair regrowth with few side effects.
research Drug repositioning: current approaches and their implications in the precision medicine era
Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.
research Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine
Some plants used in traditional medicine may help treat cancer because they contain proteins that can inactivate ribosomes.
research Finasteride
Finasteride treats enlarged prostate, improves urinary flow, but may cause sexual side effects.
research The Pharmacologic Basis of the Cardiovascular Toxicity of Minoxidil in the Dog
Minoxidil can harm dog's heart.
research How drug repurposing can advance drug discovery: challenges and opportunities
Drug repurposing is a faster, cheaper way to develop new treatments using existing drugs.
research Anthralin/dithranol in dermatology
Anthralin is effective for psoriasis and alopecia with minimal systemic side effects but can irritate the skin.
research Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution
Tretinoin cream boosts minoxidil absorption, possibly improving hair loss treatment.
research Contribution of androgens to chronic allograft nephropathy is mediated by dihydrotestosterone
Male hormones worsen kidney transplant damage, but blocking them helps.
research Recent Formulation Advances of Mangiferin
Improved delivery methods can enhance mangiferin's effectiveness as a health supplement.
research Drug repositioning using in silico compound profiling
Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.
research Topical Minoxidil
Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.
research Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells
Icariin helps mouse hair grow by boosting a growth factor in skin cells.
research Emerging Therapies for Acne Vulgaris
New acne treatments show promise as alternatives to traditional therapies.
research Efficient Intradermal Delivery of Superoxide Dismutase Using a Combination of Liposomes and Iontophoresis for Protection against UV-Induced Skin Damage
Liposomes and iontophoresis effectively deliver protective enzymes into the skin against UV damage.
research Passive and Iontophoretic Delivery of Three Diclofenac Salts across Various Skin Types.
Diclofenac salt delivery through skin varies based on the salt's counterions.
research High-performance liquid chromatographic method for the determination of finasteride in human plasma at therapeutic doses
Reliable method detects finasteride in human plasma at low doses.