research Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5α-reductase II
SPET-085 effectively inhibits an enzyme linked to prostate issues, similar to finasteride.
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900-930 / 1000+ resultsresearch Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole
Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.
research Selective inhibition by minoxidil of prostacyclin production by cells in culture
Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.
research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system
The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.
research The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis
mTOR inhibitors may help treat lung fibrosis.
research Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus
Neurosteroids help balance brain signals when certain inhibitions are reduced.
research Review of Fluconazole Properties and Analytical Methods for Its Determination
Fluconazole is an effective antifungal medication with potential side effects and lacks official analytical methods for its determination.
research Recent Formulation Advances of Mangiferin
Improved delivery methods can enhance mangiferin's effectiveness as a health supplement.
research Pharmacotherapy of polycystic ovary syndrome - an update
New treatments for PCOS show promise, but no current medication treats all aspects of the condition.
research Pharmacology of different progestogens: the special case of drospirenone
Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.
research 1250 Development of an ex vivo human skin explant model to examine candidate gene functions in the hair follicle and epidermis
The model can effectively test gene functions and drug responses in human skin.
research Indian Gooseberry (Emblica officinalisGaertn.)
Indian Gooseberry has potential for cancer prevention and treatment and promotes hair growth.
research Topical Eflornithine
Eflornithine cream effectively reduces women's unwanted facial hair but hair returns if treatment stops.
research Experimental and Clinical Pharmacology ofZiziphus jujubaMills
Ziziphus jujuba Mills may have health benefits, but more research is needed to confirm its safety and effectiveness.
research XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity
XMU-MP-1 stops cell growth in a human mini-organ and reduces the effectiveness of the chemotherapy drug paclitaxel.
research Miscellaneous Steroids
The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.
research Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.
Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.
research Management of Hirsutism
Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.
research Dutasteride reduces alcohol’s sedative effects in men in a human laboratory setting and reduces drinking in the natural environment
Dutasteride makes alcohol less sedating and may lead to less drinking in men.
research 877 Loss of UBE2N in keratinocytes leads to skin inflammation and immune infiltration through IRAK1/4-mediated processes
Removing UBE2N from skin cells causes inflammation and immune response, which can be lessened with specific inhibitors.
research Protein Kinase C as a Therapeutic Target
Protein Kinase C shows promise for cancer treatment, but more research is needed to develop effective inhibitors.
research Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.
research A review of the treatment of male pattern hair loss
Finasteride and minoxidil work best together for hair loss.
research Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5α-reductase
Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.
research Platycladus orientalis Leaves: A Systemic Review on Botany, Phytochemistry and Pharmacology
The leaves of Platycladus orientalis have potential health benefits but require more research for safety and understanding how they work.
research Molecular Docking Studies and ADME Prediction of Novel Isatin Analogs with Potent Anti-EGFR Activity
Some new isatin compounds could be strong cancer-fighting drugs because they fit well in cancer-related proteins and have good drug-like properties.
research Polycystic ovary syndrome: diagnosis and management of related infertility
Lifestyle changes and clomiphene are first-line treatments for infertility in women with PCOS, with other options available if these fail.
research Finasteride 1 mg has no inhibitory effect on omeprazole metabolism in extensive and poor metabolizers for CYP2C19 in Japanese
Finasteride doesn't affect omeprazole metabolism in Japanese people.
research Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells
A new method using human lung cells helps find drugs to block and reduce inflammation from SARS-CoV-2.
research Cedrol mitigates hepatic lipid accumulation and adipocyte hypertrophy induced by corticosteroids through the inhibition of glucocorticoid receptor activity
Cedrol may help reduce liver fat and fat cell growth caused by corticosteroids.