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The study introduces a novel approach for treating acute inflammatory visceral pain (AIVP) using dexmedetomidine-loaded hyaluronic acid hydrogel microneedles (MN/Dex). This method offers a minimally invasive, patient-friendly alternative to traditional intravenous administration, which can be uncomfortable and pose infection risks. The microneedles enable efficient skin penetration and controlled drug release, demonstrating excellent biocompatibility in biosafety evaluations. In a mouse model of AIVP, MN/Dex significantly reduced pain without causing sedation or affecting normal behaviors, suggesting its potential to improve outpatient management and quality of life for patients with AIVP.

The study highlights the growing role of pharmacists in the aesthetic market, emphasizing their importance in guiding the use of dermocosmetics and performing certain aesthetic procedures. It is a qualitative, descriptive literature review that underscores the pharmacist's technical-scientific training in skin care, cosmetic actives, formulations, pharmacology, toxicology, and biosafety. The findings suggest that pharmacists contribute to the rational use of cosmetic products, prevent adverse reactions, and provide individualized patient care. The study concludes that aesthetic pharmacy expands the professional scope of pharmacists, enhances their market value, and promotes safer, ethical, and more qualified aesthetic practices.