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Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

research Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan

926 citations , June 2010 in “BMC Medicine”

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction

182 citations , June 2017 in “Biomaterials”

Special fiber materials boost the healing properties of certain stem cells.

research Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells

92 citations , August 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.

research Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies

82 citations , March 2016 in “Autoimmunity reviews”

Animal models have helped understand hair loss from alopecia areata and find new treatments.

Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations , August 1999 in “Developmental biology”

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

research The impact of oxidative stress on hair

59 citations , November 2015 in “International Journal of Cosmetic Science”

Oxidative stress damages hair and contributes to aging, and managing it can help maintain hair health.

research Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

48 citations , January 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Chemokine signaling is important for hair development.

Clinical, Histopathological and Immunological Characteristics of Exfoliative Cutaneous Lupus Erythematosus in 25 German Short-Haired Pointers

research Clinical, histopathological and immunological characteristics of exfoliative cutaneous lupus erythematosus in 25 German short‐haired pointers

38 citations , August 2005 in “Veterinary dermatology”

A disease causing skin issues in young adult German short-haired pointers is hereditary, with most affected dogs not responding to treatment.

research FOXN1 deficient nude severe combined immunodeficiency

32 citations , January 2017 in “Orphanet journal of rare diseases”

FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.

research WNT10Ai> , dermatology and dentistry

30 citations , June 2021 in “British Journal of Dermatology”

Mutations in the WNT10A gene can cause skin, hair, teeth, and other disorders, and may also affect other areas like kidney and cancer, with potential for targeted treatments.

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs
26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research The Molecular Basis of Androgen Insensitivity
25 citations , January 2000 in “Hormone Research in Paediatrics”

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

research Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay
21 citations , January 2018 in “PLoS Genetics”

Certain genetic variants in keratins increase the risk of tooth decay.

research An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome
20 citations , May 2013 in “International Journal of Molecular Medicine”

Researchers found a new gene variant linked to a rare bone disease, which doesn't always cause symptoms in carriers.

research In vitro biomimetic platforms featuring a perfusion system and 3D spheroid culture promote the construction of tissue-engineered corneal endothelial layers
14 citations , April 2017 in “Scientific Reports”

Using a perfusion system and 3D spheroid culture improves the growth of corneal cell layers for tissue engineering.

research No improvement in male-pattern hair loss using laser hair-comb therapy: a 6-month, half-head, assessor-blinded investigation in two men
13 citations , October 2011 in “Clinical and Experimental Dermatology”

Laser hair-comb therapy doesn't improve male-pattern hair loss.

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-Ri>) in the Hairless Gene (Hri>)
10 citations , January 2010 in “Veterinary pathology”

A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.

research Lamellar ichthyosis with pseudoexon activation in the transglutaminase 1 gene
10 citations , March 2015 in “Journal of dermatology”

The boy's severe skin disorder is caused by two new mutations in his TGM1 gene.

research Autosomal recessive congenital ichthyosis due to PNPLA1i> mutation in a golden retriever–poodle cross‐bred dog and the effect of topical therapy
9 citations , May 2016 in “Veterinary dermatology”

Long-term oral and topical treatments improved skin condition in a goldendoodle with a genetic disorder.

research Rapid full engraftment and successful immune reconstitution after allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in Omenn syndrome
8 citations , August 2009 in “Pediatric transplantation”

A five-month-old boy with Omenn syndrome successfully recovered after a stem cell transplant with reduced intensity conditioning.

research Targeted elimination of the follicular label-retaining cells by photo-induced cell killing caused a defect on follicular renewal on mice
8 citations , September 2002 in “Genes to Cells”

Killing specific cells in hair follicles can lead to hair growth problems in mice.

research Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study
6 citations , September 2019 in “Skin pharmacology and physiology”

RCS-01 therapy is safe and may improve skin structure by affecting gene expression.

research Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms onListeria monocytogenesi>infection
6 citations , October 2017 in “Oncotarget”

Hairless mice are more vulnerable to Listeria infection, but gut microbiota can help reduce damage.

research Epigenetic regulations on skin wound healing: implications from current researches.
5 citations , September 2015 in “PubMed”

Epigenetic changes are crucial for stem cell behavior in skin wound healing and their disruption may lead to cancer.

research 3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa
4 citations , June 2021 in “Dermatology”

Scientists created a 3D skin model to study a chronic skin disease and test treatments.

research Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis
4 citations , February 2018 in “Journal of Investigative Dermatology”

The document concludes that a protein involved in hair growth may link to baldness and that more research is needed on its role in hair loss and skin cancer treatments.

research Novel Missense Mutation in the P-Box of Androgen Receptor in a Patient with Androgen Insensitivity Syndrome
3 citations , January 2008 in “Endocrine journal”

A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.

research Natural course of epidermolysis bullosa simplex with mottled pigmentation in a Japanese family with the p.P25L mutation in KRT 5 i>
3 citations , January 2019 in “Journal of Dermatology”

The p.P25L mutation in the KRT5 gene causes a rare skin condition that worsens over time and may lead to hair loss starting in young adulthood.

research The PER3 rs772027021 SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria
2 citations , September 2022

The PER3 rs772027021 SNP may cause mild skin pigmentation changes in a new subtype of dyschromatosis universalis hereditaria.

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research Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

research Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction

research Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells

research Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies

research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research The impact of oxidative stress on hair

research Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development

research Clinical, histopathological and immunological characteristics of exfoliative cutaneous lupus erythematosus in 25 German short‐haired pointers

research FOXN1 deficient nude severe combined immunodeficiency

research WNT10Ai> , dermatology and dentistry

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

research The Molecular Basis of Androgen Insensitivity

research Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay

research An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome

research In vitro biomimetic platforms featuring a perfusion system and 3D spheroid culture promote the construction of tissue-engineered corneal endothelial layers

research No improvement in male-pattern hair loss using laser hair-comb therapy: a 6-month, half-head, assessor-blinded investigation in two men

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-Ri>) in the Hairless Gene (Hri>)

research Lamellar ichthyosis with pseudoexon activation in the transglutaminase 1 gene

research Autosomal recessive congenital ichthyosis due to PNPLA1i> mutation in a golden retriever–poodle cross‐bred dog and the effect of topical therapy

research Rapid full engraftment and successful immune reconstitution after allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in Omenn syndrome

research Targeted elimination of the follicular label-retaining cells by photo-induced cell killing caused a defect on follicular renewal on mice

research Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study

research Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms onListeria monocytogenesi>infection

research Epigenetic regulations on skin wound healing: implications from current researches.

research 3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa

research Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis

research Novel Missense Mutation in the P-Box of Androgen Receptor in a Patient with Androgen Insensitivity Syndrome

research Natural course of epidermolysis bullosa simplex with mottled pigmentation in a Japanese family with the p.P25L mutation in KRT 5 i>

research The PER3 rs772027021 SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria