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research Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application

53 citations , September 2020 in “Stem Cell Research & Therapy”

New methods to improve the healing abilities of mesenchymal stem cells for disease treatment are promising but need more research.

research Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice

49 citations , August 2004 in “The FASEB Journal”

Mice with human skin protein K8 had more skin problems and cancer.

Polycystic Ovary Syndrome and Other Androgen Excess-Related Conditions: Can Changes in Dietary Intake Make a Difference?

research Polycystic Ovary Syndrome (PCOS) and Other Androgen Excess–Related Conditions: Can Changes in Dietary Intake Make a Difference?

48 citations , February 2008 in “Nutrition in Clinical Practice”

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

47 citations , March 2019 in “Journal of immunology research”

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Adrenal Disorders and the Pediatric Brain: Pathophysiological Considerations and Clinical Implications

research Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications

38 citations , January 2014 in “International Journal of Endocrinology”

Adrenal disorders can cause lasting brain and behavior issues in children.

Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

research Lymphoid Enhancer-binding Factor-1 (LEF1) Interacts with the DNA-binding Domain of the Vitamin D Receptor

37 citations , April 2011 in “Journal of Biological Chemistry”

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

research The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana tropicalisi>

37 citations , January 2009 in “Sexual Development”

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

research Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation
36 citations , January 2018 in “Scientific reports”

Eating glucoraphanin can help prevent psychosis in offspring whose mothers had immune system activation.

research The Efficacy of 24-Month Metformin for Improving Menses, Hormones, and Metabolic Profiles in Polycystic Ovary Syndrome
33 citations , January 2018 in “The Journal of Clinical Endocrinology & Metabolism”

Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.

research Prognosis and Management of Congenital Hair Shaft Disorders with Fragility—Part I
33 citations , June 2016 in “Pediatric Dermatology”

Some congenital hair disorders improve in childhood or with treatments like minoxidil and retinoids, while others like Netherton syndrome and trichothiodystrophy have a poor prognosis.

research Exogenous calreticulin improves diabetic wound healing
33 citations , September 2012 in “Wound Repair and Regeneration”

Applying calreticulin can speed up wound healing in diabetics.

research The influence of interferon on healthy and diseased skin
32 citations , December 2018 in “Cytokine”

Type I interferons play a key role in the development of various skin diseases.

research Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation
32 citations , April 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Loss of keratin K2 causes skin problems and inflammation.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men
31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

research Metabolic aspects of different phenotypes of polycystic ovary syndrome: Iranian PCOS Prevalence Study
31 citations , January 2014 in “Clinical Endocrinology”

The study suggests that being overweight or obese, not PCOS itself, is strongly linked to insulin resistance.

research Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia
31 citations , January 2003 in “Dermatology”

Steroidogenic isoenzymes may help improve treatments for common hair loss.

research The Role of Immature and Mature Adipocytes in Hair Cycling
30 citations , December 2018 in “Trends in Endocrinology and Metabolism”

Both immature and mature fat cells are important for hair growth cycles, with immature cells promoting growth and mature cells possibly inhibiting it.

research Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE−/− mice fed western diet
30 citations , July 2018 in “Scientific Reports”

Blocking certain fat production can reverse skin inflammation and hair loss.

research Synaptic processes and immune-related pathways implicated in Tourette syndrome
29 citations , January 2021 in “Translational Psychiatry”

The research suggests that Tourette syndrome is linked to both brain signaling and immune system pathways.

research Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice
29 citations , June 2018 in “Scientific Reports”

15-lipoxygenase helps keep skin healthy by reducing inflammation.

research Clinical characteristics of polycystic ovary syndrome: investigating differences in White and South Asian women
29 citations , March 2015 in “Clinical Endocrinology”

South Asian women with PCOS present with different symptoms compared to White women, influenced by ethnicity, obesity, and age.

research The ITGB6 gene: its role in experimental and clinical biology
28 citations , November 2019 in “Gene”

The ITGB6 gene is important for tissue repair and hair growth, and mutations can lead to enamel defects and other health issues.

research Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation?
28 citations , November 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

GMG-43AC may help reduce unwanted hair growth and treat certain hair loss conditions.

research Finasteride is the main inhibitor of 5α-reductase activity in microdissected dermal papillae of human hair follicles
28 citations , February 1999 in “Archives of Dermatological Research”

Finasteride potentially treats hair loss by reducing DHT production.

research Immune cell regulation of the hair cycle
27 citations , January 2020 in “Experimental Dermatology”

Immune cells affect hair growth and could lead to new hair loss treatments.

research Group IID, IIE, IIF and III secreted phospholipase A2s
23 citations , August 2018 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

research Getting under the skin of hair aging: the impact of the hair follicle environment
20 citations , May 2020 in “Experimental Dermatology”

Aging scalp skin contributes to hair aging and loss, and more research is needed to develop better hair loss treatments.

research Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction
20 citations , June 2017 in “Hormone Molecular Biology and Clinical Investigation”

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

research Decreased lipin 1β expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome
20 citations , October 2008 in “European journal of endocrinology”

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

research PCOS in lesbian and heterosexual women treated with artificial donor insemination
20 citations , January 2008 in “Reproductive Biomedicine Online”

Sexual orientation does not affect the prevalence of PCOS or fertility rates in women undergoing artificial donor insemination.

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