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GlossaryPinacidil

Pinacidil is a potassium channel opener that has been studied for its potential role in promoting hair growth and treating hair loss. It works by enhancing blood flow to hair follicles and may stimulate hair regrowth by prolonging the anagen (growth) phase of the hair cycle. Unlike other hair loss treatments, pinacidil is not a topical minoxidil derivative but shares similar mechanisms in promoting vasodilation and improving follicular health. Its relevance lies in its potential as an alternative or adjunct therapy for conditions like androgenetic alopecia.

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research Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells

16 citations , July 1994 in “Journal of Dermatological Science”

Minoxidil sulfate and pinacidil may promote hair growth through increased blood flow, not by activating potassium channels.

research Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol–response curve in porcine detrusor muscle

3 citations , March 2012 in “Arab Journal of Urology”

Certain drugs can reduce bladder muscle contractions, potentially helping treat bladder diseases.

research Potassium Channel Openers Stimulate DNA Synthesis in Mouse Epidermal Keratinocyte and Whole Hair Follicle Cultures

31 citations , January 1993 in “Skin Pharmacology and Physiology”

Potassium channel openers can boost hair growth by stimulating DNA in hair follicles.

research Effect of K+ channel openers on K+ channel in cultured human dermal papilla cells.

20 citations , August 1997 in “PubMed”

Increased K+ permeability alone may not promote hair growth.

research Enhanced in vitro hair growth at the air-liquid interface: minoxidil preserves the root sheath in cultured whisker follicles

12 citations , July 1993 in “In Vitro Cellular & Developmental Biology - Animal”

Minoxidil enhances hair growth and preserves the root sheath in cultured follicles.

research ANDROGENETIC ALOPECIA

5 citations , May 1994 in “Facial plastic surgery clinics of North America”

Minoxidil was promising for treating male and female pattern baldness in 1994, but more research on genetics and other treatments was needed.

Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells

research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome K_ATPChannel Mutations in Intact Cells

1 citations , August 2023 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

research Ultrastructural Localization and Quantification of Extracellular Calcium Binding Sites in Mouse Vibrissa and Human Scalp Follicles

1 citations , January 1993 in “Skin Pharmacology and Physiology”

Hair growth drugs and epidermal growth factor do not change the calcium binding site gradient in hair follicles.

research Hormonal Control of Cardiac Action Potential Phase 1 Currents in the Brugada Syndrome

February 2014 in “Revista Argentina de Cardiología”

Androgens may increase arrhythmias in Brugada Syndrome, while Finasteride could reduce them.

research 任意方向の負荷に対する多自由度機構の出力変位誤差評価 : 評価法の提案と3自由度空間パラレルメカニズムの高剛性化(機械力学,計測,自動制御)

January 2005 in “日本機械学會論文集. C編”

Minoxidil sulfate and pinacidil promote hair growth likely by increasing blood flow, not by activating K channels.

research ENHANCED IN VITRO HAIR GROWTH AT THE AIR-LIQUID MINOXIDIL PRESERVES THE ROOT SHEATH IN CULTURED WHISKER FOLLICLES INTERFACE:

January 1993

Culturing hair follicles at the air-liquid interface with minoxidil significantly boosts hair growth and preserves the root sheath.

The Role of ATP-Sensitive Inward Rectifier Potassium Channels in the Regulation of Reactive Oxygen Species in the Western Honey Bee, Apis Mellifera L.

research The Role of ATP-Sensitive Inward Rectifier Potassium Channels In The Regulation of Reactive Oxygen Species In The Western Honey Bee, APIS Mellifera L.

June 2022

Activating certain potassium channels in honey bees can lower antioxidant levels and reduce death rates during heavy mite infestations, potentially aiding their immune response.

research Potassium channel openers: pharmacological and clinical aspects

119 citations , October 1992 in “Fundamental & Clinical Pharmacology”

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations , December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research Potassium channel openers: therapeutic potential in cardiology and medicine

25 citations , December 2001 in “Expert Opinion on Pharmacotherapy”

Potassium channel openers show promise for treating heart disease and other conditions, but more research is needed to fully understand their effects and safety.

research Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process

13 citations , May 2011 in “Bioorganic & Medicinal Chemistry”

Changing the 6-position on benzopyran molecules affects insulin release, with some compounds showing strong inhibitory effects.

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

research Minoxidil: mechanisms of action on hair growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Minoxidil Use in Dermatology, Side Effects and Recent Patents

152 citations , April 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery”

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

research Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle

149 citations , March 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

research Drug-Induced Hair Loss and Hair Growth

147 citations , April 1994 in “Drug Safety”

Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.

research K _ATP Channels and Cardiovascular Disease

144 citations , March 2013 in “Circulation Research”

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

Potassium Channel Therapeutics at the Bedside

research K channel therapeutics at the bedside

119 citations , June 2005 in “Journal of Molecular and Cellular Cardiology”

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil

research Human hair follicles contain two forms of ATP‐ sensitive potassium channels, only one of which is sensitive to minoxidil

102 citations , February 2008 in “The FASEB Journal”

One minoxidil-sensitive potassium channel exists in human hair follicles.

research The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim

86 citations , July 1990 in “British Journal of Pharmacology”

Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.

research Hair growth and rejuvenation: An overview

81 citations , June 2010 in “Journal of Dermatological Treatment”

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells

research Alopecia Areata

49 citations , November 1992 in “Archives of dermatology”

Different treatments for alopecia areata have varying success rates and side effects; intralesional steroids are most effective.