research Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.
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120-150 / 1000+ results research Open-Label, Randomized, Multicenter, Phase III Study Comparing Oral Paclitaxel Plus Encequidar Versus Intravenous Paclitaxel in Patients With Metastatic Breast Cancer
Oral paclitaxel plus encequidar improved tumor response and caused less neuropathy but more serious infections than intravenous paclitaxel.
research Standardized Informed Consent Form for Clinicians Administering Platelet-Rich Plasma
A standardized consent form for PRP injections improves patient trust and legal protection.
research The safety profiles of avacopan on microscopic polyangiitis and granulomatosis with polyangiitis: a real-world pharmacovigilance analysis
Avacopan is generally safe, with some minor side effects like nausea and fatigue.
research Doxazosin + finasteride in BPH with TPV ??? 25mL
research Platelet-rich fibrin in the management of oral mucosal lesions: a scoping review
Platelet-rich fibrin shows promise for treating oral lesions but needs more research.
research Drug repurposing—a promising approach for patients with angina but non-obstructive coronary artery disease (ANOCA)
Using existing drugs for new purposes could be a cost-effective way to treat chest pain and non-clogged heart arteries, with some drugs for lung blood pressure showing promise but needing more testing.
research Platelet-Rich Plasma Therapy for Male and Female Pattern Hair Loss
research The Effect of Simvastatin on Plasma Steroid Hormone Levels in Metformin-Treated Women with Non-Classic Congenital Adrenal Hyperplasia
Simvastatin may help manage symptoms in women with non-classic congenital adrenal hyperplasia by lowering cholesterol and certain hormone levels.
research Platelet-Rich Plasma for Degenerative Spine Disease: A Brief Overview
PRP shows promise for spinal pain but needs more guidelines before widespread use.
research Reporting on Adverse Clinical Events
Certain medications can reduce mortality risk in COPD patients, but others can increase risks of cardiovascular issues, postoperative delirium, and other adverse effects.
research Prescribers alerted to potential adverse effects of finasteride and montelukast
research A Football Player with Thrombocytopenia
Athletes with low platelet counts need careful monitoring and informed discussions about playing contact sports safely.
research Localized cutaneous necrosis associated with the antiphospholipid syndrome
A woman with lupus experienced skin death due to a blood clotting disorder after stopping a blood thinner, which healed with treatment.
research 1492 Prostacyclin pathway to enhance wound healing in diabetic foot ulcers
Treprostinil, a drug, can delay wound healing in healthy cells but doesn't affect diabetic foot ulcer cells, suggesting further research could help understand its role in treating these ulcers.
research Valproate-Induced Hair Loss: What to Tell Patients
research Sodium valproate and thrombocytopenia.
Sodium valproate can cause low platelet count.
research Tratamiento ortobiológico con plasma rico en plaquetas. Revisión sistemática y clasificación de la evidencia
PRP treatment lacks strong evidence for routine use due to poor study quality.
research Management of pilonidal sinus disease with lyopreserved umbilical tissue allograft placement: a case series
Using lyopreserved umbilical tissue allograft may improve healing and reduce recurrence of pilonidal cysts.
research Two cases of stroke associated with the use of finasteride，an approved drug for male-pattern hair loss in Japan
Finasteride, a hair loss medication, may be linked to stroke in young men.
research The Role of Platelet-Rich Plasma in the Prevention of Chemotherapy-Induced Alopecia
Platelet-rich plasma doesn't prevent hair loss from chemotherapy, and mononuclear cells only help against hair loss from one specific chemotherapy drug.
research Pharma maker recalls drug over undeclared anti-hypertensive drug
A medicine company has recalled a drug because it contained an unlisted blood pressure medication.
research Abstract SS02-02: Chemoprevention: Poised for Success
Chemoprevention can significantly lower cancer risks and needs more research and collaboration.
research Generalised cutaneous necrosis: a complication of low-molecular-weight heparin
A woman developed severe skin damage after using a blood thinner called low-molecular-weight heparin.
research UK High Court Revokes Escitalopram UK Patent; Validity of Second Medical use Claims Based on Dosage Regimes in the UK; Stay of Proceedings in the UK Courts Pending EPO Opposition Proceedings
The UK High Court revoked Lundbeck's patent for Escitalopram, and second medical use claims based on dosage were not considered novel.
research Repurposing of drugs as novel influenza inhibitors from clinical gene expression infection signatures
Existing drugs, including a blood pressure medication, show promise as new treatments for influenza.
research miR-150 regulates endothelial progenitor cell differentiation via Akt and promotes thrombus resolution
miR-150 helps blood vessel cells develop and speeds up blood clot healing.
research Abstract 313: Finasteride Delays Atherosclerosis Progression and Reduces Hepatic Inflammation in Low-density Lipoprotein Receptor-deficient Mice
Finasteride may slow down heart disease by lowering cholesterol and reducing inflammation.
research Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)
BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.