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GlossaryPolyethylenimine

polymer used for binding DNA and delivering genes

Polyethylenimine (PEI) is a polymer that is often used in scientific research and industrial applications due to its strong ability to bind to DNA and other negatively charged molecules. It is commonly utilized in gene therapy and biotechnology for delivering genetic material into cells, as well as in water treatment processes to remove contaminants.

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research The use of polyethylenimine–DNA to topically deliver hTERT to promote hair growth

17 citations , May 2011 in “Gene Therapy”

Using polyethylenimine-DNA to deliver the hTERT gene can stimulate hair growth and may be useful in treating hair loss, but there could be potential cancer risks.

Homogeneous Silver Nanoparticle Loaded Polydopamine/Polyethyleneimine-Coated Bacterial Cellulose Nanofibers for Wound Dressing

research Homogeneous silver nanoparticle loaded polydopamine/polyethyleneimine-coated bacterial cellulose nanofibers for wound dressing

5 citations , July 2023 in “International journal of biological macromolecules”

The new wound dressing material speeds up healing, fights infection, and outperforms traditional dressings.

research Influence of urea on the coloring ability of a low‐temperature coloring method of keratin fibers using polyethyleneimine

5 citations , January 2004 in “Journal of applied polymer science”

Urea helps hair dye penetrate better and last longer.

research Triton modified polyethyleneimine conjugates assembled with growth arrest-specific protein 6 for androgenetic alopecia transdermal gene therapy

February 2023 in “Materials today bio”

The treatment effectively promotes hair regrowth in androgenetic alopecia without causing skin irritation.

Epidermal Stem Cells Manipulated by pDNA-VEGF165/CYD-PEI Nanoparticles Loaded Gelatin/β-TCP Matrix as a Therapeutic Agent and Gene Delivery Vehicle for Wound Healing

research Epidermal Stem Cells Manipulated by pDNA-VEGF165/CYD-PEI Nanoparticles Loaded Gelatin/β-TCP Matrix as a Therapeutic Agent and Gene Delivery Vehicle for Wound Healing

40 citations , June 2013 in “Molecular Pharmaceutics”

The gelatin/β-TCP scaffold with nanoparticles improves wound healing and skin regeneration.

research Injectable self-healing ceria-based nanocomposite hydrogel with ROS-scavenging activity for skin wound repair

26 citations , December 2021 in “Regenerative Biomaterials”

The hydrogel speeds up skin wound healing and helps regenerate tissue.

research Multifunctional DNA Hydrogels with Hydrocolloid‐Cotton Structure for Regeneration of Diabetic Infectious Wounds

83 citations , September 2021 in “Advanced functional materials”

The DNA hydrogel helps heal diabetic wounds by absorbing fluids, warming, sticking to tissue, killing bacteria, and aiding tissue and hair regrowth.

research Bioorthogonal Catalytic Microneedles Based on a Cytotoxic PEI Matrix for Synergistic Melanoma Therapy

April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

A new microneedle patch significantly improves melanoma treatment by using a special material to activate cancer-fighting drugs and disrupt cancer cells.

research New method of dyeing keratin fibers using poly(ethylene imine) and its coloring mechanism

6 citations , October 2003 in “Journal of applied polymer science”

A new method using poly(ethylene imine) improves hair dyeing at lower temperatures with better color retention.

research Diffusion behavior of poly(ethylene imine) into keratin fibers using microspectrophotometry

5 citations , April 2005 in “Journal of applied polymer science”

PEI diffuses into hair at a constant rate, and urea speeds up this process.

research The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics

47 citations , February 2021 in “Pharmacological research”

Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.

Surface Modification and Endothelialization of Biomaterials as Potential Scaffolds for Vascular Tissue Engineering Applications

research Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

421 citations , January 2015 in “Chemical Society Reviews”

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Bioactive Anti-Inflammatory Antibacterial Hemostatic Citrate-Based Dressing With Macrophage Polarization Regulation for Accelerating Wound Healing and Hair Follicle Neogenesis

research Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

61 citations , September 2020 in “Bioactive Materials”

A special dressing called FEA-PCEI can speed up wound healing, reduce scars, and help grow new hair follicles, but only at the right dosage.

research Engineering Cell Surfaces with Polyelectrolyte Materials for Translational Applications

15 citations , January 2017 in “Polymers”

Polyelectrolytes can improve cell surfaces for better medical applications.

research Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

65 citations , July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine

65 citations , November 2012 in “Tissue Engineering Part B-reviews”

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

research Spatiotemporal control of CRISPR/Cas9 gene editing

51 citations , June 2021 in “Signal Transduction and Targeted Therapy”

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Nanoparticles in Wound Healing: From Hope to Routine

research Nanoparticles in wound healing from hope to promise from promise to routine

48 citations , September 2017 in “Frontiers in Bioscience”

Nanoparticles show promise for better wound healing, but more research is needed to ensure safety and effectiveness.

research Modern drug delivery strategies applied to natural active compounds

39 citations , September 2016 in “Expert Opinion on Drug Delivery”

New drug delivery methods can make natural compounds more effective and stable.

Genetically-Manipulated Adult Stem Cells as Therapeutic Agents and Gene Delivery Vehicles for Wound Repair and Regeneration

research Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration

36 citations , August 2011 in “Journal of Controlled Release”

Genetically-altered adult stem cells can help in wound healing and are becoming crucial in regenerative medicine and drug design.

research Applications and Risks of Nanomaterials Used in Regenerative Medicine, Delivery Systems, Theranostics, and Therapy

28 citations , January 2017 in “Critical Reviews in Therapeutic Drug Carrier Systems”

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

research Critical Role of ATP-P2X7 Axis in UV-Induced Melanogenesis

23 citations , March 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

ATP increases melanin production in skin after UV exposure, with the P2X7 receptor being crucial for this process.

research Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

23 citations , January 2016 in “Theranostics”

Minoxidil-coated microbubbles with sonication effectively enhance hair growth.

research Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid

23 citations , January 2014 in “Molecular Therapy”

Applying a special DNA plasmid to the skin can make it thicker and stronger.

research Brain-targeted intranasal delivery of protein-based gene therapy for treatment of ischemic stroke

14 citations , January 2024 in “Theranostics”

Intranasal delivery of gene therapy shows promise for treating ischemic stroke.

research Emerging lipid–polymer hybrid nanoparticles for genome editing

10 citations , January 2024 in “Polymer Chemistry”

Lipid–polymer hybrid nanoparticles can improve genome editing delivery and outcomes.

research Accelerated Wound Healing Using Nanoparticles

10 citations , January 2016 in “Elsevier eBooks”

Nanoparticles can speed up wound healing and deliver drugs effectively but may have potential toxicity risks.

research Trends in Nanotechnology for Practical Applications

9 citations , October 2018 in “Elsevier eBooks”

Nanotechnology is improving drug delivery and targeting, with promising applications in cancer treatment, gene therapy, and cosmetics, but challenges remain in ensuring precise delivery and safety.

research Basic concepts, current evidence, and future potential for gene therapy in managing cutaneous wounds

6 citations , June 2019 in “Biotechnology Letters”

Gene therapy shows promise for improving wound healing, but more research is needed for human use.

METTL1-Mediated m7G tRNA Modification Drives Papillary Thyroid Cancer Progression and Metastasis by Regulating the Codon-Specific Translation of TNF-α

research METTL1-mediated m7G tRNA modification drives papillary thyroid cancer progression and metastasis by regulating the codon-specific translation of TNF-α

3 citations , May 2025 in “Cell Death and Disease”

Targeting METTL1 may help slow papillary thyroid cancer growth and spread.