research Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus
Neurosteroids help balance brain signals when certain inhibitions are reduced.
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240-270 / 1000+ resultsresearch Re-Evaluating Platelet-Rich Plasma Dosing Strategies in Sports Medicine: The Role of the “10 Billion Platelet Dose” in Optimizing Therapeutic Outcomes—A Narrative Review
Higher platelet doses in PRP therapy improve outcomes for musculoskeletal issues.
research Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice
GABAergic steroid precursors reduce ethanol withdrawal symptoms in certain mice.
research Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis
Corticosterone makes ethanol more effective at blocking brain processes important for learning and memory.
research Morphologische und histochemische Untersuchungen von Haut. Schleimhäuten und Klauen bei Schweinen mit experimentellem Biotinmangel4
Biotin deficiency in pigs causes hair loss, skin issues, and weak claws.
research Prefrontal 5α-reductase 2 mediates male-specific acute stress response
5α-reductase 2 is crucial for stress response in male rats.
research Effectiveness of Low-dose Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel with and without Metformin on Hirsutism in Polycystic Ovary Syndrome: A Randomized, Double-blind, Triple-dummy Study.
Both oral contraceptives reduced hirsutism in PCOS patients, but adding metformin showed no extra benefit.
research Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men
Dutasteride helps reduce heavy drinking, especially for those who drink to cope.
research Role of Silver Nanoparticles in Wound Healing: Mechanisms, Efficacy, and Clinical Applications
Silver nanoparticles help heal wounds by preventing infections and promoting tissue repair.
research Changes in Prolactin and Insulin Resistance in PCOS Patients Undergoing Metformin Treatment: A Retrospective Study
Lower baseline prolactin levels may lead to better insulin resistance improvement with metformin in PCOS patients.
research Suicidality Risks Associated with Finasteride, a 5-Alpha Reductase Inhibitor: An Evaluation of Real-World Data from the FDA Adverse Event Reports
Finasteride use may increase suicidality risk, especially in young men.
research NEONATAL INHIBITION OF ANDROGEN ACTIVITY ALTERS THE PROGRAMMING OF BODY WEIGHT AND OREXINERGIC PEPTIDES DIFFERENTIALLY IN MALE AND FEMALE RATS
Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.
research Effect of Neurosteroids on Basal and Stress-Induced Oxytocin Secretion in Luteal-Phase and Pregnant Sheep
Neurosteroids help regulate oxytocin levels, especially during stress and pregnancy, to protect against premature labor.
research Early postnatal inhibition of neurosteroid synthesis changes the later-life adverse outcome of neonatal asphyxia in rats
Finasteride reduced seizures and prevented cognitive issues in rats after neonatal asphyxia but increased anxiety later.
research BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FINASTERIDE, TADALAFIL, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS
A reliable method was developed to measure Finasteride and Tadalafil in rat blood.
research Stable isotope analyses of carbon and nitrogen in hair keratin of suspected man-eating wolves from 1880s
The wolves suspected of man-eating in the 1880s likely ate very little human flesh and mostly consumed a diet similar to herbivores and omnivores.
research First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.
ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.
research 1433 Epithelially derived, mitochondrial MPZL3 negatively regulates murine and human hair follicle cycling
A protein called MPZL3 in mitochondria slows down hair growth and could be a target for treating hair growth disorders.
research LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis
Substance P may contribute to hair loss by increasing oxidative stress and mitochondrial activity in hair follicles.
research 715 Hunting the hair cycle clock (HCC): Evidence that mitochondrially localized MPZL3 is a key HCC element in murine and human hair follicles
MPZL3 is important for controlling the hair growth cycle in mice and humans.
research Low-Dose Flutamide (125 mg/Day) as Maintenance Therapy in the Treatment of Hirsutism
Low-dose flutamide effectively maintains reduced hirsutism with no side effects.
research Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids
Chronic ethanol increases certain brain receptor levels, influenced by steroids and protein changes.
research Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats
Hormonal contraceptives may reduce social behavior and sexual motivation by lowering allopregnanolone levels.
research Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies
Different rat and mouse strains respond differently to stress and alcohol, which may help us understand similar human mechanisms.
research Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids
Ethanol changes GABAA receptor α4 subunit levels through phosphorylation and neuroactive steroids.
research Porocarcinoma: an epidemiological, clinical, and dermoscopic 20‐year study
Porocarcinoma generally has low rates of recurrence, spread to lymph nodes, and death.
research Molecular, immunological, enzymatic and biochemical studies of coproporphyrinogen oxidase deficiency in a family with hereditary coproporphyria.
A new gene mutation causes hereditary coproporphyria with reduced enzyme activity.
research G4, is a new transgenic mouse model for the polycystic ovaries syndrome
Researchers created a new mouse model, G4, that mimics human PCOS symptoms and links the condition to a specific gene.
research A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21.
Pachyonychia congenita is linked to a keratin gene on chromosome 17.
research Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions
Paxillin may help manage androgen-related disorders like PCOS by stabilizing androgen receptor proteins.