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Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with fewer side effects.

GTx-024 and Danazol affect the uterus like DHT, while GTx-007 has little impact.

Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.

The diphosphonate was the most effective at preventing calcification in rats.

Activating δ-opioid receptors can help hair grow.

The retinoid receptor antagonist effectively disrupts vitamin A-related development in embryos.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Inhibiting certain enzymes made female rats more sensitive to low-level pain.

Antiandrogens are used to manage polycystic ovary syndrome by reducing androgen levels or controlling their effects, often combined with lifestyle changes and other treatments.

Cyproterone acetate effectively treats sexual disorders by reducing sexual functions and is generally well-tolerated.

Neurosteroids affect prolactin levels in sheep differently depending on stress and pregnancy conditions.

Kojyl cinnamate ester derivatives can promote hair growth by increasing adiponectin production in fat tissues.

Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

Certain existing drugs, like glycopyrronium and botulinum toxin type A, may help treat excessive sweating.

New curcumin analogues help fight prostate cancer by breaking down androgen receptors.

Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.

Dopamine agonists like pramipexole and ropinirole can cause reversible hair loss.

A peptide known for reducing wrinkles also effectively inhibits an enzyme linked to skin inflammation and acne.

Anti-androgens can help manage some PCOS symptoms better than metformin but are not more effective than placebos or birth control pills for other symptoms.

Blocking DPP4 can potentially speed up hair growth and regeneration, especially after injury or in cases of hair loss.

Gender-affirming hormone therapy affects metabolism differently based on treatment type.

MPA improved hormonal imbalances and acne in women with PCOS without affecting metabolism.

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

Hydroxypinacolone retinoate is a potent anti-aging ingredient for skin that is more effective and less irritating than other forms of retinoids.

Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.

PCOS women have more severe metabolic issues and higher androgen levels than hyperandrogenic women without PCOS.

Allopregnanolone helps control oxytocin levels during pregnancy to prevent preterm labor.