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Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth

research Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth

38 citations , June 2018 in “Plant & cell physiology/Plant and cell physiology”

Changing the amount of PLC5 in Arabidopsis affects root growth and drought resistance, with less PLC5 slowing root growth and more PLC5 improving drought tolerance but hindering root hair growth.

research Supplementary Methods, Tables 1-2 and Figures from Tumor Stroma–Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of <i>Ptch</i>-Mutant Mice via CaMKII

March 2023

research Structure of human type II 5 alpha-reductase gene

76 citations , September 1992 in “Endocrinology”

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

research Wnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration

16 citations , January 2016 in “International Journal of Medical Sciences”

Wnt5a slows down hair growth by blocking a specific pathway during hair regeneration.

research Subcellular localization of the five members of the human steroid 5α-reductase family

13 citations , June 2017 in “Biochimie open”

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

research SlPHL1, a MYB‐CC transcription factor identified from tomato, positively regulates the phosphate starvation response

11 citations , July 2021 in “Physiologia Plantarum”

SIPHL1 from tomato enhances plants' response to low phosphate levels.

research Mutation of a type II keratin gene (K6a) in pachyonychia congenita

232 citations , July 1995 in “Nature Genetics”

Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research 1365 Elf5, a novel regulator of skin stem/progenitor cells fate during skin development?

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Elf5 is important for skin stem cell growth and could help treat skin and hair problems.

research A frameshift mutation in the TRPS1 gene showing a mild phenotype of trichorhinophalangeal syndrome type 1

1 citations , December 2018 in “Journal of genetic medicine”

A small change in the TRPS1 gene leads to a less severe form of a syndrome affecting hair, nose, and finger development.

research Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

70 citations , August 2006 in “Cancer Research”

AP-1 controls tumor cell type by affecting key signaling pathways.

research Finasteride: a 5 alpha-reductase inhibitor.

12 citations , January 1993 in “PubMed”

research Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression

47 citations , February 2014 in “Journal of Cutaneous Pathology”

Matrical tumors share a common growth mechanism involving the Wnt pathway and consistent PHLDA1 expression.

research A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.

46 citations , May 1995 in “Proceedings of the National Academy of Sciences”

A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.

research A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb

5 citations , June 2008 in “British Journal of Dermatology”

research 0955 Selective BET inhibition as potential hidradenitis suppurativa treatment

July 2025 in “Journal of Investigative Dermatology”

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration

April 2019 in “Journal of Investigative Dermatology”

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

research Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages

July 2025 in “Pharmaceutics”

Recombinant Human Annexin A5 may help treat localized scleroderma by reducing skin thickening and inflammation.

research CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling

28 citations , November 2018 in “Journal of Cellular and Molecular Medicine”

CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.

research PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats

1 citations , April 2025 in “BMC Veterinary Research”

PSAT1 is key for hair growth and stem cell function in cashmere goats.

research 865 Conditional ablation of JAK-STAT5 signaling induces anagen hair growth

April 2017 in “Journal of Investigative Dermatology”

Blocking JAK-STAT5 signaling in mice leads to hair growth.

research Antipsychotic-Like Properties of 5-α-Reductase Inhibitors

64 citations , March 2008 in “Neuropsychopharmacology”

research Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in this Gene Family for its Expression in the Adult Mouse Tail and Ear¹

16 citations , May 2000 in “Endocrinology”

A new gene, mrp4, is found in mice and may play a unique role in hair follicle development in tails and ears.

research Impairment of Hair-Inducing Capacity of Three-Dimensionally Cultured Human Dermal Papilla Cells by the Ablation of STAT5

1 citations , January 2019 in “Annals of dermatology/Annals of Dermatology”

STAT5 is crucial for hair growth in 3D cultured human dermal papilla cells.

research HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF‐β/Smad signaling pathway in CARASIL model mice

3 citations , July 2022 in “Brain and Behavior”

The HtrA1L364P mutation causes brain dysfunction and blood vessel damage.

research Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data

5 citations , January 2018 in “Interdisciplinary sciences: computational life sciences”

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

research Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity

372 citations , December 2004 in “Nature Genetics”

research 576 INTASYL PH-762: Intratumoral immunotherapy targeting PD-1

July 2024 in “Journal of Investigative Dermatology”

PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.

research PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect

June 2025 in “Proceedings of the National Academy of Sciences”

A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.

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