research First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.
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research Síndrome PRIDE: una práctica forma de identificar los efectos adversos cutáneos de los inhibidores del EGFR
PRIDE syndrome helps identify skin side effects from EGFR inhibitors like erlotinib.
research Observational Study of Paclitaxel-Carboplatin versus Pemetrexed-Carboplatin for Advanced Pulmonary Adenocarcinoma at Single-Centre in Indonesia
Both treatments are similarly effective, but paclitaxel-carboplatin is cheaper and has more severe side effects.
research Repurposed Drugs: Current Trends in Drug Discovery
Drug repurposing speeds up development, cuts costs, and uses known safe drugs, but faces challenges like regulations and patents.
research Towards Better Regulation in Cosmetic Practice Post-Keogh
The conclusion is that improved training and oversight for cosmetic procedures are recommended to better protect patients.
research Repurposed Drugs
Repurposing existing drugs can save time and money in finding new treatments.
research Probing neuronal functions with precise and targeted laser ablation in the living cortex
The laser system helps study brain cell functions by precisely removing specific cells and observing changes.
research USO DE ESTIMULAÇÃO CEREBRAL PROFUNDA (DBS) PARA O TRATAMENTO DA DOENÇA DE PARKINSON
Deep Brain Stimulation helps manage Parkinson's symptoms when medication isn't enough.
research Reproducibility of global photographic assessments of patients with male pattern baldness in a clinical trial with finasteride.
A trial found that using finasteride, a hair growth drug, can be effectively measured by comparing before and after photos.
research Role of Drug Repurposing in Sustainable Drug Discovery
Drug repurposing speeds up drug development, saves money, and has led to about a third of new drug approvals.
research THERAPEUTIC EFFICACY OF PRACCHANA KARMA IN THE AYURVEDIC MANAGEMENT OF SHWITRA (VITILIGO): A CASE REPORT
Ayurvedic treatment, including Pracchana Karma, successfully improved vitiligo in a young woman.
research Drug Repurposing: Accelerating New Therapeutic Discoveries from Old Molecules (1990 – 2025)
Repurposing existing drugs can quickly and cheaply find new treatments.
research A regulatory perspective on pharmacokinetic/pharmacodynamic modelling
The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.
research Experimental protocol designed to employ Nd:YAG laser surgery for anterior chamber glaucoma detection via UBM
Targeting the narrowest part of the anterior chamber angle may help prevent pupil block in glaucoma.
research A comparative study of therapeutic response to intralesional injections of platelet-rich plasma versus triamcinolone acetonide in alopecia areata
PRP works faster and is a safe alternative to steroids for treating alopecia areata.
research A HISTOCHEMICAL TEST FOR CITRULLINE ADAPTATION OF THE CARBAMIDO DIACETYL REACTION TO HISTOLOGIC SECTIONS WITH POSITIVE RESULTS IN PILOMATRIXOMAS (CALCIFYING EPITHELIOMAS)
A new test more accurately detects citrulline in hair follicles and pilomatrixomas.
research A consideration when interpreting outpatient data
Objective assessment is needed to accurately determine medication use and adherence.
research Quality of life in Romanian patients with schizophrenia based on gender, type of schizophrenia, therapeutic approach, and family history
Men and patients on atypical antipsychotics have better mental functioning and quality of life.
research A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels
The conclusion is that a new test was created to find substances that affect specific ion channels, and it works well for drug discovery.
research Follow-Up of 1 mg Finasteride Treatment of Male Pattern Baldness-Difference between Clinical Trials and Private Office Follow-Up: Influences on Prescribing Habits Evaluated
Finasteride showed limited hair growth and low patient compliance in treating male pattern baldness.
research Innovations in skin microphysiological systems for nonclinical testing and FDA modernization
New technologies replicate human skin for testing without animals.
research Early postnatal neuroactive steroid manipulation differentially affects recognition memory and passive avoidance performance in male rats
Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.
research Influence of knowledge and beliefs on consumption of performance enhancing agents in north-western Saudi Arabia
More knowledge about the risks of performance-enhancing agents leads to less use in north-western Saudi Arabia.
research Health-related quality of life with sacituzumab govitecan in HR+/HER2− metastatic breast cancer in the phase III TROPiCS-02 trial
Sacituzumab govitecan improves quality of life and symptoms in breast cancer patients, except for causing more diarrhea.
research Moving Chemoprevention Forward into the Most Promising Areas of Study
Further research is needed to develop effective cancer prevention strategies.
research Alternative and Complimentary Medicines in the management of Chronic Breast Cancer: A discrete choice cost and clinical case report
Alternative therapies like mushrooms and vinegar extracts can improve health and reduce costs for breast cancer patients.
research A Comprehensive Study on Quasi-Drugs Regulations in Japan and South Korea
Quasi-drugs in Japan and South Korea are regulated to ensure safety and effectiveness, offering products with mild therapeutic effects.
research Variables affecting the potential efficacy of PRP in providing chronic pain relief
Standardizing PRP preparation and application could improve its effectiveness for chronic pain relief.
research Identification of Trichophyton rubrum by Nested PCR Analysis from Paraffin Embedded Specimen in Trichophytia Profunda Acuta of the Glabrous Skin
Nested PCR can reliably identify fungal infections when traditional methods fail.
research Clinical comparison of extended-release divalproex versus delayed-release divalproex: pooled data analyses from nine trials
Extended-release divalproex is better tolerated and more effective for seizures and psychiatric symptoms than delayed-release divalproex, but doesn't reduce hair loss.