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Search for New Antineoplastic Agents Based on Structural Modifications of Steroidal 5α-Reductase, 17β-Hydroxysteroid Dehydrogenase, and 17α-Hydroxylase/17,20-Lyase Inhibitors

research Search for New antineoplastic agents based on structural modifications of steroidal 5α-reductase, 17β-hydroxysteroid dehydrogenase, and 17α-hydroxylase/17,20-lyase inhibitors

November 2025 in “Russian Journal of Oncology”

Modifying steroidal inhibitors shows promise for developing new cancer treatments.

research Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin

11 citations , August 2000 in “Journal of Endocrinology”

DHEA acts like a male hormone on rat skin glands and doesn't turn into female hormones there.

research Consecutive Cyproterone Acetate and Estradiol Treatment in Late-Pubertal Transgender Female Adolescents

36 citations , May 2017 in “The journal of sexual medicine”

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

research Which chemicals should be grouped together for mixture risk assessments of male reproductive disorders?

40 citations , September 2019 in “Molecular and Cellular Endocrinology”

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research Studies of the components of an oral contraceptive agent in albino rats. II. Progestogenic component and comparison of effects of the components and the combined agent

24 citations , July 1980 in “Journal of Toxicology and Environmental Health”

High doses of norethindrone acetate in rats caused various organ changes but didn't significantly increase tumor rates.

research In silico structural prediction of human steroid 5α-reductase type II

3 citations , March 2016 in “Medicinal Chemistry Research”

Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.

research Dehydroepiandrosterone- and glucose-6-phosphate-dehydrogenases in the hair cycle of the rat

7 citations , January 1971 in “Archives of Dermatological Research”

research Hyperandrogenic eumenorrheic NON-PCOS women versus women with PCOS after the GnRH-agonist stimulation test preceded by suppression of adrenal steroidogenesis with dexamethasone

1 citations , September 2024 in “Journal of Clinical & Translational Endocrinology”

PCOS women have more severe metabolic issues and higher androgen levels than hyperandrogenic women without PCOS.

research Mechanisms responsible for progesterone's protection against lordosis-inhibiting effects of restraint II. Role of progesterone metabolites

9 citations , May 2011 in “Hormones and Behavior”

Allopregnanolone, a progesterone metabolite, helps reduce restraint effects on behavior.

research Breaking the ‘rule-of-five’ to access bridged bicyclic heteroaromatic bioisosteres

February 2026 in “Nature Synthesis”

A new method creates unique chemical structures that could improve drug discovery.

research Progesterone-induced spike-wave discharges are inhibited by finasteride

January 2004 in “Data Archiving and Networked Services (DANS)”

Finasteride blocks progesterone's effect on brain activity linked to epilepsy.

research The effect of an oral contraceptive containing ethinylestradiol and desogestrel on hair growth and hormonal parameters of hirsute women

11 citations , October 1986 in “International Journal of Gynecology & Obstetrics”

The contraceptive reduced hair growth and altered hormone levels in hirsute women.

research Neonatal neurosteroid levels are determinant in shaping adult prepulse inhibition response to hippocampal allopregnanolone in rats

18 citations , January 2013 in “Psychoneuroendocrinology”

Neonatal neurosteroid levels affect adult brain function and behavior.

Pharmacological Activity and Clinical Use of Polydeoxyribonucleotide

research Pharmacological Activity and Clinical Use of PDRN

80 citations , April 2017 in “Frontiers in Pharmacology”

PDRN helps repair tissue and improve wound healing with a high safety profile.

research Expression of NAD+dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle

11 citations , March 2008 in “Experimental Dermatology”

A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.

research EFFECTS OF A LOW‐DOSE DESOGESTREL‐ETHINYLESTRADIOL COMBINATION ON HIRSUTISM, ANDROGENS AND SEX HORMONE BINDING GLOBULIN IN WOMEN WITH A POLYCYSTIC OVARY SYNDROME

53 citations , January 1985 in “Acta obstetricia et gynecologica Scandinavica”

Low-dose oral contraceptives reduced hair growth and testosterone levels in women with polycystic ovary syndrome.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research PMON319 A Pure Androgen Secreting Adrenal - Cortical Tumor in a 13 Year Old Female

November 2022 in “Journal of the Endocrine Society”

A 13-year-old girl's masculine symptoms improved after surgery for a rare adrenal tumor that produced male hormones.

research Contraceptive Implants

14 citations , April 2005 in “African Journal of Reproductive Health”

Contraceptive implants are effective, long-lasting, and safe with manageable side effects.

research Treatment of androgenetic alopecia in females in reproductive age with topical estradiolbenzoate, prednisolon and salicylic acid.

1 citations , January 2000 in “PubMed”

The treatment slightly increased hair growth and was safe for most women.

research Structural studies of two solid steroid compounds

2 citations , January 2006 in “Durham e-Theses (Durham University)”

Androsterone and finasteride have different solid forms, with new findings correcting previous errors and identifying a new form.

research Treating psychogenic nonepileptic seizures: Easier said than done

8 citations , February 2003 in “Annals of Neurology”

Progesterone treatment improved seizures in a woman with menstrual cycle-related epilepsy, but a wrong medication worsened her condition.

research Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2

5 citations , November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.

Virilizing Malignant Steroid Cell Tumor: Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Histopathological and Biochemical Challenges: A Case Report

research A Virilizing Malignant Steroid Cell Tumor-Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Challenging Histopathological and Biochemical Features: A Case Report

April 2023 in “Research Square (Research Square)”

A young woman had a rare, aggressive ovarian tumor that was hard to diagnose and treat, leading to disease progression despite treatment.

research Finasteride blocks progesterone synthesis in MA-10 Leydig tumor cells.

6 citations , October 1993 in “Endocrinology”

Finasteride blocks progesterone production in specific tumor cells, potentially causing side effects.

research Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on fetal guinea pig brain development.

63 citations , December 2010 in “Journal of Endocrinology”

Reduced neurosteroids and growth issues can harm fetal brain development, especially in males.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research AN ATTEMPT TO ASSESS THE MAGNITUDE OF ENDOGENOUS ANDROGEN PRODUCTION IN A CASE OF THE ADRENOGENITAL SYNDROME*

9 citations , August 1952 in “The Journal of Clinical Endocrinology & Metabolism”

A 17-year-old female with adrenogenital syndrome produces very high levels of androgens, which prevent complete feminization despite high estrogen doses.

research 701 Signaling networks between stem cell precursors, transit amplifying progenitors, and their niche in developing hair follicles

April 2016 in “Journal of Investigative Dermatology”

Blocking Prostaglandin D₂ (PGD₂) could help treat hair loss.

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