research Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.
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research Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases
Certain drugs that block specific enzymes can help treat prostate diseases.
research Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner
Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.
research Safety concerns when using novel medications to treat alopecia
Consider benefits and risks of new alopecia treatments for safety.
research Improvement of General Symptoms in a Chronic Psychotic Patient Treated with Finasteride: Case Report
Finasteride improved symptoms in a schizophrenia patient.
research Androgens in Women – Critical Evaluation of the Methods for Their Determination in Diagnostics of Endocrine Disorders
The conclusion is that standardizing testosterone measurement methods is essential for better diagnosis accuracy in women.
research Progestogens in menopausal hormone therapy
Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.
research Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring—Preliminary Study
Father's finasteride use may affect son's fertility and testicular function.
research Medical Treatment of Alopecia
The most effective treatments for hair loss are minoxidil, finasteride, PRP, and hair transplants, with steroids and immunosuppressants for autoimmune types.
research Ethanol intake patterns in female mice: Influence of allopregnanolone and the inhibition of its synthesis
Female mice are less affected by certain substances that alter alcohol consumption compared to male mice.
research Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice
GABAergic steroid precursors reduce ethanol withdrawal symptoms in certain mice.
research The effect of finasteride on anxiety in rats
Finasteride may increase anxiety in bright spaces.
research The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors
DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.
research Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats
Inhibiting certain enzymes made female rats more sensitive to low-level pain.
research Null Mutation of 5α-Reductase Type I Gene Alters Ethanol Consumption Patterns in a Sex-Dependent Manner
research Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells
Allopregnanolone changes gene expression in glioblastoma cells.
research Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice
Progesterone reduces anxiety and depression in female mice by increasing BDNF in the brain, needing 5α-reduction and estradiol.
research Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men
Dutasteride helps reduce heavy drinking, especially for those who drink to cope.
research Androgens’ Effects across the Lifespan in Men and Animal Models
Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.
research Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice.
Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.
research Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.
Neuroactive steroids affect cocaine's rewarding effects through the sigma1 receptor.
research Activation of extrasynaptic δ-GABAA receptors globally or within the posterior-VTA has estrous-dependent effects on consumption of alcohol and estrous-independent effects on locomotion
δ-GABAA receptors affect alcohol consumption based on the estrous cycle and influence movement regardless of the cycle.
research Mechanisms of Action of Dehydroepiandrosterone
DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.
research Anxiolytic activity of progesterone in progesterone receptor knockout mice
Progesterone reduces anxiety without needing progesterone receptors.
research Simultaneous Determination of Selected Steroids with Neuroactive Effects in Human Serum by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry
A new method accurately measures nine neuroactive steroids in small blood samples, helping to study brain diseases.
research The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration
Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.
research Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome
Women with PCOS have distinct retinal changes compared to healthy women.
research Dihydrotestosterone and Finasteride Effects on Alcohol Cue‐Elicited Brain Activity in Males With Heavy Episodic Drinking
Finasteride may help reduce alcohol cravings and related brain activity.
research 5α-Reductases In Human Physiology: an Unfolding Story
We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
research Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats
Allopregnanolone affects fear responses differently in male and female rats, possibly explaining sex differences in anxiety disorders.