15 citations
,
July 1968 in “JAMA” Severe itching can be an early sign of hyperthyroidism.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The back of the scalp has more nerve fibers than the front, which may explain why some people feel more sensitivity there.
109 citations
,
November 2011 in “Nature Neuroscience”
April 2017 in “InTech eBooks” Many people with hair loss experience scalp pain known as trichodynia, but the causes are unclear and treatments vary.
March 2005 in “Journal of The American Academy of Dermatology” Itch is a common symptom in patients with chronic venous insufficiency, often accompanied by burning and pain.
January 2025 in “Journal of the Egyptian Womenʼs Dermatologic Society” Higher substance P levels may cause discomfort in hair loss patients.
11 citations
,
July 1968 in “JAMA” Itching can be an early sign of hyperthyroidism.
Scalp itching can be caused by various skin conditions, hair loss, allergies, or anxiety.
61 citations
,
October 2011 in “Experimental dermatology” Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.
1 citations
,
August 2021 in “Journal of The American Academy of Dermatology” Ice cooling and vibration can reduce pain during PRP scalp injections without affecting treatment effectiveness.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” HSD11b1 affects skin nerves and increases non-histaminergic itch.
7 citations
,
January 2015 in “Hair therapy & transplantation” Air pollution can cause hair loss, and using antioxidants, special shampoos, and coconut oil can improve scalp health and hair density.
15 citations
,
December 1972 in “Journal of Investigative Dermatology” October 2014 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” A new type of nerve cell involved in itch perception was discovered.
41 citations
,
April 2009 in “Journal of comparative neurology” P2X3-IR fibers are widespread in rat skin and likely help detect pain.
7 citations
,
July 2025 in “The Journal of Physiology” C-tactile nerves are sensitive to hair movement.
1 citations
,
June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” The symposium highlighted the skin's role in sensing itch, pain, touch, and pleasure, and discussed new research and techniques for understanding and treating these sensations.
27 citations
,
October 2002 in “International Journal of Dermatology” Trichostasis spinulosa causes itchy bumps on young adults' skin.
5 citations
,
March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Dynamic, light touch is sensed through a common mechanism involving Piezo2 channels in sensory axons.
May 1987 in “Inpharma (Balgowlah)” Topical minoxidil may slow hair loss but often doesn't lead to satisfactory hair regrowth and requires ongoing treatment.
4 citations
,
January 2021 in “Skin appendage disorders” Trichodynia is a painful scalp condition not directly linked to the amount or type of hair loss and may involve psychological factors, with treatments showing mixed results.
May 2011 in “Value in Health” CP-690,550 significantly reduced itching in patients with moderate-to-severe plaque psoriasis.
31 citations
,
November 2016 in “Cell Reports” Touch sensitivity in mouse skin decreases during hair growth due to changes in touch receptors.
January 2000 in “Neuroscience Research”
4 citations
,
April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The skin has about 230,000 touch-sensitive nerve fibers, with high concentrations in the hands and face.
142 citations
,
September 2020 in “Journal of neurophysiology” Young adults have about 230,000 tactile nerve fibers, decreasing 5-8% per decade with age.
April 2018 in “Selçuk Üniversitesi Tıp Fakültesi dergisi” Repeated PRP injections for hair loss can cause increased pain sensitivity.
July 2024 in “Journal of Investigative Dermatology” Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.
7 citations
,
January 1998 in “PubMed” Hair loss can cause scalp discomfort.
35 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” Intralesional triamcinolone acetonide is effective for treating patchy hair loss, and dermoscopy helps detect treatment response and side effects early.