11 citations
,
November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.
August 2019 in “Placenta” Being overweight or obese before pregnancy increases the risk of having a C-section and a larger-than-normal baby in Chile's public health system.
7 citations
,
September 1988 in “Baillière's clinical obstetrics and gynaecology” Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.
3 citations
,
January 2003 in “Synthetic Communications” Scientists made two new chemicals that might help treat diseases caused by male hormones.
14 citations
,
April 2005 in “African Journal of Reproductive Health” Contraceptive implants are effective, long-lasting, and safe with manageable side effects.
1 citations
,
January 2001 in “Endocrine Practice” Topical finasteride may help treat facial hirsutism in women.
18 citations
,
December 2014 in “Obstetrics and Gynecology Clinics of North America” Losing 5-10% body weight can improve PCOS symptoms, letrozole is better than clomiphene for fertility, and managing weight and blood sugar is important to reduce pregnancy complications.
164 citations
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January 2003 in “Drugs”
10 citations
,
January 2015 in “Przeglad Menopauzalny” Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.
September 2024 in “Cermin Dunia Kedokteran” Different progestins work similarly for contraception but have unique effects suited to individual needs.
November 2014 in “Clinical Neurophysiology” High doses of progesterone can reduce seizures in mice.
20 citations
,
January 2003 in “Chemical and Pharmaceutical Bulletin” The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
123 citations
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June 2006 in “Journal of Neurobiology” Progesterone protects brain cells, but Provera does not.
17 citations
,
January 2004 in “European journal of obstetrics, gynecology, and reproductive biology/European journal of obstetrics & gynecology and reproductive biology” Certain hormone medications can treat symptoms like acne and unwanted hair, regulate periods, and prevent pregnancy in women and teenage girls.
1 citations
,
April 2013 in “The FASEB Journal” 3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.
11 citations
,
May 2022 in “World Journal of Biological Chemistry” Progesterone may help trans women with breast development and health, but more research is needed.
June 2014 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” Progesterone and its metabolites can prevent seizures without major side effects.
14 citations
,
March 2017 in “Brain research” Progesterone and its byproducts control a specific receptor in the brain independently of progesterone receptors, affecting conditions related to the menstrual cycle.
21 citations
,
January 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.
26 citations
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November 2013 in “Neuroscience” Progesterone can reduce seizures without relying on the GABAA receptor pathway.
22 citations
,
January 2001 in “Chemical & Pharmaceutical Bulletin” Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.
13 citations
,
May 2007 in “Journal of Endocrinology” Synthetic 19-norprogestins promote bone cell growth and function through their non-phenolic metabolites.
January 2020 in “Nihon Yakuri Gakkai nenkai yoshishu” Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.
December 2023 in “Frontiers in pharmacology” Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.
4 citations
,
January 2025 in “International Journal of Molecular Sciences” Progesterone reduces anxiety and depression in female mice by increasing BDNF in the brain, needing 5α-reduction and estradiol.
13 citations
,
January 2005 in “Chemical and Pharmaceutical Bulletin” Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.
21 citations
,
February 2005 in “Epilepsy & Behavior” Reducing 3α,5α-THP in the hippocampus increases seizures in female rats.
25 citations
,
July 2006 in “Journal of Neurochemistry” Progesterone affects GABAA receptor function by altering δ subunit levels.
83 citations
,
November 2006 in “European Journal of Neuroscience” Progesterone protects rat brain cells by enhancing GABA A receptor activity.
180 citations
,
June 2004 in “Journal of Pharmacology and Experimental Therapeutics” Progesterone's seizure-reducing effects are mainly due to allopregnanolone, not progesterone receptors.