21 citations
,
May 2016 in “Progress in Neuro-Psychopharmacology and Biological Psychiatry” Diazepam's effects on anxiety and memory differ between male and female rats due to hormonal influences.
16 citations
,
November 2011 in “Neuroscience Letters” Progesterone protects brain cells by converting to allopregnanolone and involving GABAA receptors.
11 citations
,
May 2010 in “Journal of Medicinal Chemistry” A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.
9 citations
,
May 2011 in “Hormones and Behavior” Allopregnanolone, a progesterone metabolite, helps reduce restraint effects on behavior.
June 2026 in “Scientific Reports” Testosterone makes XX skin more like male skin by changing its structure and cell makeup.
September 2024 in “International Journal of Molecular Sciences” High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.
January 2010 in “Acta Universitatis Medicinalis Nanjing” Progesterone helps adult male mice's brain cells survive and improves learning and memory.
March 2008 in “The FASEB Journal” Neurosteroid withdrawal increases α4 subunit expression in the hippocampus, which may relate to catamenial epilepsy in women.
December 2023 in “Frontiers in pharmacology” Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.
A mix of Polygonatum sibiricum and Nelumbinis semen may ease menopause symptoms with fewer side effects.
March 2023 in “Revista médica Clínica Las Condes” The study suggests a possible increase in androgen receptors in patients with frontal fibrosing alopecia, but more research is needed.
147 citations
,
April 2004 in “PubMed” Sex steroid receptors are found in specific skin cells, affecting skin and hair functions.
91 citations
,
May 2003 in “PubMed” Neuroactive steroids affect cocaine's rewarding effects through the sigma1 receptor.
85 citations
,
May 2009 in “Hippocampus” Progesterone helps adult male mice grow more neurons and improves memory.
30 citations
,
February 2003 in “Annals of Neurology” Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.
27 citations
,
April 2007 in “European Journal of Pharmacology” Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.
26 citations
,
November 2013 in “Neuroscience” Progesterone can reduce seizures without relying on the GABAA receptor pathway.
15 citations
,
April 2008 in “Steroids” The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
April 2008 in “Annals of General Psychiatry” Social isolation changes brain receptors and makes ethanol more impactful.
1 citations
,
April 2013 in “The FASEB Journal” 3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.
1 citations
,
April 2011 in “The FASEB Journal” Progesterone-derived neurosteroids affect GABA-A receptor expression, influencing epilepsy during menstrual cycles.
83 citations
,
November 2006 in “European Journal of Neuroscience” Progesterone protects rat brain cells by enhancing GABA A receptor activity.
17 citations
,
October 2015 in “The Journal of Physiology” Combining progesterone with caffeine worsens breathing issues in newborns.
12 citations
,
September 2002 in “Journal of Neurochemistry” Pregnancy-related hormone changes affect Y1 receptor gene expression in mice.
238 citations
,
February 2007 in “Journal of Neuroscience” Ovarian and stress hormones can change GABA A receptors through neurosteroids.
34 citations
,
November 2017 in “Gynecological Endocrinology” A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.
17 citations
,
April 2006 in “Brain Research” 5α-reduced neurosteroids may help regulate glial cell differentiation.
11 citations
,
January 2014 in “CellBio” Sex steroids, especially progesterone, can slow down the growth of mouse melanoma cells.
11 citations
,
November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.
3 citations
,
January 2016 in “Elsevier eBooks” Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.