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Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

Polycystic ovary syndrome affects about 6-10% of women, with varying symptoms and the need for standardized global definitions.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.

Cyproterone acetate-estrogen most effective for hirsutism, but consider side effects and patient needs.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Neurosteroids regulate synaptic inhibition in the spinal cord and may help manage spinal pain.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Prolactin slows down hair growth in mice.

Certain drugs that block specific enzymes can help treat prostate diseases.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Phosphatidic acid may help hair grow by affecting cell growth pathways.