The PI's development is closely linked to skin and hair pigmentation in macaques.
7 citations
,
October 2010 in “Medical Hypotheses” Alopecia areata may involve stress-related changes affecting hormone receptors, leading to reduced cortisol production.
16 citations
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April 1998 in “Journal of Investigative Dermatology” ACTH promotes hair growth in mink, but α-MSH does not.
12 citations
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December 1981 in “Journal of Endocrinology” α-MSH increases melanin production in moulting hair follicles, while AVT inhibits it.
53 citations
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July 1981 in “Journal of Endocrinology” α-MSH and cyclic AMP boost melanin production, while cyclic GMP and melatonin reduce it.
3 citations
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May 1979 in “PubMed” 103 citations
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April 2005 in “Experimental dermatology” Prostaglandin F2alpha and related compounds can increase hair growth and darken hair in mice.
12 citations
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September 2018 in “International Journal of Cosmetic Science” Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.
77 citations
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December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.
135 citations
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March 2000 in “Journal of Biological Chemistry” Agouti and AGRP affect pigmentation and obesity, with implications for metabolic disorders.
2 citations
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October 1999 in “Annals of the New York Academy of Sciences” Melatonin and cortisol affect mink winter hair growth, but β-endorphin levels do not.
April 2015 in “한국생물공학회 학술대회” Finasteride reduces melanin production in skin cells.
70 citations
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December 2004 in “Proceedings of the National Academy of Sciences” BMP signaling affects hair color by interacting with the MC-1R pathway.
109 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.
January 2008 in “Linchuang pifuke zazhi” Betamethasone activates and increases the growth of certain skin cells from hair follicles.
April 2026 in “The FASEB Journal” Exosomal miR-199a-3p from dermal papilla cells helps control hair color by affecting melanocytes.
November 2025 in “Journal of Investigative Dermatology” Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.
8 citations
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June 2004 in “Journal of Investigative Dermatology” Certain peptides can prevent hair loss in young rats caused by a cancer drug.
3 citations
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May 2020 in “Acta pharmaceutica” Protocatechuic acid can reduce melanin production and boost antioxidant activity in hair follicles.
9 citations
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January 2019 in “Postepy Dermatologii I Alergologii” The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.
June 2006 in “Almustansiriya journal of pharmaceutical sciences/Al-Mustansiriyah journal of pharmaceutical sciences” Melatonin may help reduce the needed dose of prednisolone and improve hair growth in alopecia areata patients.
November 2025 in “Journal of Investigative Dermatology” AMP-303 injections can increase hair growth in androgenetic alopecia with minimal side effects.
10 citations
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November 2009 in “Pigment cell & melanoma research” The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.
January 2009 in “The Chinese Journal of Dermatovenereology” Higher doses of Tribulus terrestris extract increase MC-1R expression in mouse hair follicles.
9 citations
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August 2005 in “Experimental Dermatology” Modified pep7, named EPM peptide, effectively promotes hair growth at low concentrations and works well with minoxidil.
53 citations
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October 2012 in “The FASEB Journal” Bimatoprost, a glaucoma medication, may also help treat hair loss.
33 citations
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January 2002 Latanoprost, a glaucoma drug, showed potential for promoting hair growth in bald monkeys, especially at higher doses.
November 2022 in “Skin Appendage Disorders” PT-20 did not significantly improve gray hair repigmentation.
1 citations
,
July 2024 in “Journal of Investigative Dermatology” Immune cells boost stem cell activity in hairy moles, causing more hair growth.
15 citations
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April 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” A3B5 can reduce skin pigmentation and slow melanoma growth.