September 2017 in “Journal of Investigative Dermatology” BMPs are crucial for hair growth and their decrease by androgens leads to hair loss.
65 citations
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May 2010 in “Current Women's Health Reviews” Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.
21 citations
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March 2019 in “Critical Reviews in Clinical Laboratory Sciences” The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.
1039 citations
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February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
479 citations
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January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
300 citations
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August 2012 in “Seminars in Cell & Developmental Biology” The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
260 citations
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December 2012 in “Cold Spring Harbor Perspectives in Biology” Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.
179 citations
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July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.
131 citations
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July 2009 in “Experimental Dermatology” The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.
125 citations
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August 2020 in “Frontiers in Immunology” Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.
124 citations
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July 2012 in “Archives of Dermatological Research” Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
120 citations
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February 2009 in “Apoptosis” Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.
94 citations
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June 2016 in “The FASEB Journal” The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.
93 citations
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June 2011 in “Journal of Neuroscience” p63 is essential for activating and differentiating stem cells in the nose's olfactory tissue.
84 citations
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January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology” Skin stem cells help maintain skin health, grow hair, and heal wounds.
80 citations
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April 2011 in “Plant physiology” White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.
75 citations
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June 2019 in “International Journal of Molecular Sciences” Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.
74 citations
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January 2013 in “Expert Opinion on Biological Therapy” The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.
69 citations
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June 2017 in “Experimental Biology and Medicine” Advanced human skin models improve drug development and could replace animal testing.
64 citations
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March 2017 in “Nature communications” Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.
56 citations
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June 2015 in “Nature Protocols” Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.
52 citations
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June 1981 in “International Journal of Dermatology” Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
47 citations
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July 2013 in “Pharmacological Reviews” Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
46 citations
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September 2014 in “Steroids” Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.
41 citations
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December 2019 in “Stem Cell Reviews and Reports” Tooth regeneration could become possible by controlling how and when bioactive factors are released.
35 citations
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October 2017 in “Trends in Molecular Medicine” Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.
35 citations
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January 2013 in “The Journal of experimental medicine/The journal of experimental medicine” CD98hc's role in skin health decreases with age.
30 citations
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December 2018 in “International Journal of Biological Macromolecules” Chitosan and surface-deacetylated chitin nanofibers may help treat hair loss.
22 citations
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November 2011 in “Journal of Analytical Toxicology” Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.