Search

for
Search:

Sort by

Research

420-450 / 1000+ results

research Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors

16 citations , November 2018 in “The journal of pain/Journal of pain”

14,15-EET may help reduce poststroke pain by affecting certain brain proteins.

research Bioinspired peptides designed for hair perming and dyeing with potential for repair

3 citations , July 2023 in “Acta Biomaterialia”

PepACS offers a safer, eco-friendly way to perm, dye, and repair hair.

research Abietic Acid from Resina Pini of Pinus Species as a Testosterone 5.ALPHA.-Reductase Inhibitor

21 citations , January 2010 in “JOURNAL OF HEALTH SCIENCE”

Abietic acid from pine resin can effectively inhibit testosterone 5α-reductase.

research The biphasic regulatory effect of diphencyprone on mouse hair growth and its relation to protein kinase C isoforms

March 1998 in “Journal of dermatological science”

Diphencyprone initially increases mouse hair growth, then slows it, possibly due to changes in specific protein levels.

Complete Defect in PA-PLA1α Secretion Function Leading to Autosomal Recessive Woolly Hair and Hypotrichosis: Insights from a Novel Compound Heterozygous LIPH Variant Study in a Chinese Pedigree

research Complete defect in PA-PLA1α secretion function leading to autosomal recessive woolly hair and hypotrichosis: insights from a novel compound heterozygous LIPH variant study in a Chinese pedigree

May 2025 in “Frontiers in Genetics”

A new genetic variant in the LIPH gene causes hair growth issues in a Chinese patient.

research Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors

19 citations , March 2010 in “Steroids”

Certain progesterone derivatives can inhibit enzymes and reduce androgenic activity, potentially affecting prostate growth.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations , August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

research Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity

13 citations , October 2017 in “Bioorganic & Medicinal Chemistry”

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.

research Breaking the “rule-of-five” to access Bridged Bicyclic Heteroaromatic Bioisosteres

3 citations , May 2025

A new method creates valuable compounds for drug discovery by breaking traditional chemical rules.

research Functional characterization and unraveling the structural determinants of novel steroid hydroxylase CYP154C7 from Streptomyces sp. PAMC26508

4 citations , October 2024 in “Heliyon”

CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.

research Fast Motions in 5 Alpha Reductase and Its Impact on Enzyme Kinetics

May 2026 in “ACS Catalysis”

The study investigates the catalytic mechanism of steroid 5α-reductase type 2 (SRD5A2), focusing on the dynamic interactions among residues that affect enzyme kinetics. Using QM/MM simulations, it was found that residues Tyr33 and L224 compress the donor, altering free energy barriers and supporting the preorganization theory. Additionally, six other residues (Trp53, Arg94, Cys119, Glu197, Phe223, and Arg227) form a network that stabilizes transition states through electrostatic and structural interactions. The L224P mutant analysis shows that losing L224 compression increases energy barriers by 3.3-3.4 kcal/mol, highlighting the importance of dynamic and electrostatic coordination for efficient catalysis.

Protein Disulfide Isomerase-Mediated Grafting of Cysteine-Containing Peptides onto Over-Bleached Hair

research Protein disulphide isomerase-mediated grafting of cysteine-containing peptides onto over-bleached hair

28 citations , December 2011 in “Biocatalysis and biotransformation”

PDI helps restore over-bleached hair's strength and structure by attaching special peptides.

research Penggunaan Simplex Lattice Design (SLD) dalam Optimasi HPMC dan Propilen Glikol Formula Gel Cinchonine Sebagai antibakteri Cutibacterium acnes (C.Acne)

June 2025 in “Healthy-Mu Journal”

The optimized Cinchonine gel effectively fights acne bacteria and is safe for twice-daily use.

research POLEVAN®—A Multifunctional Natural Hair Ingredient, as Determined by In-Vitro and Human Studies

November 2025 in “Cosmetics”

POLEVAN® improves hair shine, moisturizes the scalp, and maintains foam quality in shampoos.

research The occurrence of the ε-(γ-glutamyl)lysine cross-link in the medulla of hair and quill

49 citations , January 1972 in “Biochimica et Biophysica Acta (BBA) - Protein Structure”

research Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

294 citations , February 1994 in “PubMed”

Valproic acid is an effective and safe first-choice treatment for many types of seizures.

research Bidirectional binding property of high glycine–tyrosine keratin-associated protein contributes to the mechanical strength and shape of hair

46 citations , June 2013 in “Journal of structural biology”

High glycine–tyrosine keratin-associated proteins help make hair strong and maintain its shape.

research Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase

6 citations , March 2003 in “Archiv Der Pharmazie”

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

December 2022 in “Scientific Reports”

Compound 4 is a promising treatment for hair loss with low toxicity.

research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate

3 citations , January 2003 in “Synthetic Communications”

Scientists made two new chemicals that might help treat diseases caused by male hormones.

research Prodrugs of butyric acid from bench to bedside: Synthetic design, mechanisms of action, and clinical applications

70 citations , January 2000 in “Drug Development Research”

New butyric acid prodrugs show promise for cancer treatment, anemia management, and protecting hair from chemotherapy damage.

research Expression of NAD+dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle

11 citations , March 2008 in “Experimental Dermatology”

A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.

The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner

research The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5‐Independent Manner

May 2025 in “Experimental Dermatology”

Triphenylphosphine oxide can increase oil production and reduce inflammation in skin cells without affecting TRPM5.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Crystal Structure and Synthesis of 17α-Acetoxy-4-bromopregn-4-ene-3,20-dione

August 2002 in “Analytical Sciences”

The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.

Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E₂through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

9 citations , November 2012 in “Biomolecules & therapeutics”

A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.

research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors

May 2022 in “Current Enzyme Inhibition”

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

research Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

253 citations , April 2009 in “Journal of Biological Chemistry”

p2y5, now called LPA6, is a receptor important for human hair growth.

research 胃切除・腸切除術後の退院指導-パンフレットを使用して-

January 2007 in “日本看護学会抄録集成人看護1”

Certain amino acids in 5AR1 and 5AR2 are crucial for binding and resistance to Finasteride.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

← Previous page Next page →