research Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition
Finasteride effectively blocks rat enzymes, but with varying methods and strength.
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research Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: An update of what we now know
Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.
research Choice of recall period for patient-reported outcome (PRO) measures: criteria for consideration
Choosing the right recall period for patient feedback is important for accurate data and depends on the disease, symptom changes, and patient impact.
research Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN
The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.
research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
research The Hair Follicle: A Paradoxical Androgen Target Organ
Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.
research Androgenic Effects on Ventricular Repolarization
ADT, especially enzalutamide, may increase the risk of heart rhythm problems and sudden death in men.
research A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride
Both drugs lower DHT levels, with GI198745 being more effective.
research Potential targets in the discovery of new hair growth promoters for androgenic alopecia
The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
research FINASTERIDE FOR CHRONIC CENTRAL SEROUS CHORIORETINOPATHY
Finasteride may help treat chronic CSC, improving vision.
research Male pattern hair loss: current understanding
Genetics and hormones cause hair loss; finasteride treats it safely.
research GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk
Researchers found 71 genetic regions linked to male pattern baldness, which account for 38% of its genetic risk.
research 6 Peripheral androgens and the role of androstanediol glucuronide
Androstanediol glucuronide is a reliable marker for hirsutism in women.
research Finasteride use in the male infertility population: effects on semen and hormone parameters
Finasteride can reduce fertility in some men, but stopping it increases sperm count.
research Androgen Conjugates: Physiology and Clinical Significance
Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.
research 8 Hair follicles and associated glands as androgen targets
Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.
research Androgens and hair loss
The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.
research Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia
5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.
research Novel synthesis of nicotinamide derivatives of cytotoxic properties
Newly made nicotinamide compounds could potentially treat cancer.
research Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride
Using finasteride or dutasteride may cause long-lasting erectile dysfunction.
research Hidradenitis suppurativa: an-androgen-dependent disorder
Hidradenitis suppurativa improves with antiandrogen therapy.
research Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae)
Eclipta alba has many health benefits and contains compounds with potential for drug development.
research Regulation of masculinization: androgen signalling for external genitalia development
Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.
research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia
Micrografts improve hair density and thickness without side effects.
research Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats
Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.
research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism.
Finasteride reduces hair growth and is safe for women with excessive hair.
research Modeling of chronic radiation-induced cystitis in mice
Researchers developed a mouse model that successfully mimics the bladder damage seen in humans after radiation therapy.
research Clinical symptoms of hyperandrogenic women diagnosed with COVID‐19
Women with high androgen levels may have more severe COVID-19 symptoms.
research Resveratrol derivatives: a patent review (2009 – 2012)
New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.
research Hormonal therapies for acne
Hormonal treatments can improve acne, but they come with potential side effects and risks.