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GlossaryProtein Stability

ability of a protein to maintain its functional shape

Protein stability refers to the ability of a protein to maintain its three-dimensional structure under various conditions, such as changes in temperature, pH, or the presence of chemicals. For a layperson, think of it like a puzzle that needs to stay together to work properly; if the pieces fall apart, the puzzle is useless. For professionals, protein stability is crucial because it affects the protein's functionality and its potential use in medical or industrial applications.

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research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.

research Mechanism of Laccase-assisted Tyrosine Grafting on Keratin using BSA as a Model Protein

October 2021 in “Authorea (Authorea)”

New hair perming method using tyrosine is gentler and can be done with a blow-dryer.

research CosmeticPotential of a Structural Protein CopolymerBased on Silk, Elastin, and Keratin

September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

SELP::KP improves hair strength, elasticity, and health, making it a promising hair cosmetic.

Crystallization and Preliminary X-Ray Analysis of the Human Androgen Receptor Ligand-Binding Domain with a Coactivator-Like Peptide and Selective Androgen Receptor Modulators

research Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators

1 citations , November 2008 in “Acta crystallographica”

Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

research Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

260 citations , January 2019 in “Pharmaceutics”

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

220 citations , March 2020 in “Advanced functional materials”

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

research Proteomic analysis of hair shaft and nail plate.

29 citations , August 2011 in “PubMed”

Hair and nail proteins, mainly keratins, are crucial for structure and can indicate health issues.

Bleached Hair as a Standard Template to Evaluate the Performance of Commercial Hair Repair Products

research Bleached Hair as Standard Template to Insight the Performance of Commercial Hair Repair Products

August 2024 in “Cosmetics”

K18® and Olaplex® both effectively repair bleached hair, improving its strength, smoothness, and overall health.

research Physico-chemical properties of modern cosmetics for styling and their effect on hair structure

April 2026

Modern hair styling products don't repair hair but improve its surface and stability.

research Keratin‐based particles for protection and restoration of hair properties

17 citations , July 2018 in “International Journal of Cosmetic Science”

Keratin-based particles safely improve hair strength, smoothness, and heat protection.

research Droplets-Based Microfluidics as a Platform to Design Food-Grade Delivery Systems Based on the Entrapped Compound Type

5 citations , August 2023 in “Preprints.org”

Droplet-based microfluidics improves delivery of bioactive compounds in food using precise encapsulation and release.

research Bio‐active designed peptide for hair keratin strengthening

March 2026 in “International Journal of Cosmetic Science”

Pal-KCV peptide strengthens hair and reduces breakage by up to 52%.

research Effect of Disulfide Bonds in Human Hair Fibers on the Melting Behavior of Their Crystalline Structure

1 citations , January 2009 in “Journal of S C C J”

Changing disulfide bonds in human hair affects its melting behavior and thermal stability.

research Hydrogen Sulfide Disturbs Actin Polymerization via S-Sulfhydration Resulting in Stunted Root Hair Growth

75 citations , August 2018 in “Plant physiology”

Hydrogen sulfide disrupts protein function and root hair growth in plants by modifying proteins.

research Reversing Time with Peptides: Mechanisms, Classifications, and Innovations in Anti-aging Interventions

May 2026 in “Commagene Journal of Biology”

Anti-aging peptides can improve skin appearance but need better delivery methods and more research.

research DSC-investigations of alpha-keratins and the specific effects of chemical treatments on human hair

January 2006

Chemical treatments weaken hair's thermal stability and structure.

research Structural Characterization and Ligand Specific Protein Interactions of Androgen Receptor

March 2008 in “The Knowledge Bank (The Ohio State University)”

SARM-induced changes in the androgen receptor are specific to each ligand and affect stability and protein interactions.

research Enzymatic Crosslinking of Amino Acids Improves the Repair Effect of Keratin on Hair Fibre

May 2023 in “Polymers”

Using enzymes to link proteins makes hair repair treatments more effective and long-lasting.

research The human keratins: biology and pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

Keratins are crucial for cell stability, wound healing, and cancer diagnosis.

research Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins

12 citations , January 2013 in “Acta Histochemica”

Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.