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This document reviews the composition of cosmetic exfoliants for keratosis pilaris skincare, analyzing 50 body scrubs from pharmacies, online, and specialized stores. It identifies 28 mechanical and 22 chemical exfoliants, with chemical exfoliants containing salicylic or glycolic acid being more effective for reducing transepidermal water loss and enhancing skin exfoliation. The study finds that 62% of products use plastic packaging and categorizes products into three price ranges, with most mechanical exfoliants in the lowest range (up to €15/100 ml or g). The review suggests chemical exfoliants, particularly those with glycolic acid, are potentially effective for keratosis pilaris, but further clinical studies are needed for reliable efficacy assessment.

The study investigated ZSYY001, a polymeric micellar paclitaxel formulation, in preclinical and phase I trials for advanced solid tumors. Preclinical tests on xenograft models showed significant tumor growth inhibition without weight loss. In the phase I trial, involving 18 patients, ZSYY001 was administered at doses up to 390 mg/m² without premedication, and no dose-limiting toxicities were observed. Common side effects included anemia and hair loss, but no acute hypersensitivity reactions occurred. The study found two partial responses and seven cases of stable disease, indicating promising antitumor activity. ZSYY001 was deemed safe, well-tolerated, and exhibited non-linear pharmacokinetics, suggesting it as a potential treatment option.