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research Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase

11 citations , January 2000 in “The Journal of Steroid Biochemistry and Molecular Biology”

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Design, synthesis and anti-tumor evaluation of novel thiohydantoin congeners as androgen receptor antagonists with in vivo study.

May 2024 in “Journal of molecular structure”

A new compound, 3a, effectively fights prostate cancer better than finasteride.

research A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch

1 citations , December 2022 in “Bioactive Materials”

The microneedle patch with quercetin, zinc, and copper effectively promotes hair regrowth for androgenic alopecia.

research Ex-vivo measurement of scalp follicular infundibulum delivery of zinc pyrithione and climbazole from an anti-dandruff shampoo

12 citations , May 2017 in “Journal of pharmaceutical and biomedical analysis”

The method shows that zinc pyrithione and climbazole from anti-dandruff shampoo effectively reach the scalp.

research Pharmacodynamics and pharmacokinetics of P-3074, a new finasteride topical solution, administered at four different doses

January 2014

P-3074 effectively blocks scalp DHT better than oral finasteride.

research Topical application of dehydroxymethylepoxyquinomicin improves allergic inflammation via NF-κB inhibition

15 citations , July 2010 in “Journal of Allergy and Clinical Immunology”

A new cream, DHMEQ, reduces allergic skin inflammation effectively.

research RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

49 citations , January 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

RU 58841 may treat acne, hair loss, and excessive hair growth.

research Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors

17 citations , December 2015 in “Bioorganic & Medicinal Chemistry”

3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.

research 43755 Rapid Reduction and Strict Complete Response in Itch With Oral Difelikefalin in Subjects With Notalgia Paresthetica and Moderate-to-Severe Pruritus

September 2023 in “Journal of the American Academy of Dermatology”

Oral difelikefalin significantly reduces itch in notalgia paresthetica.

research THE USE OF AUTORADIOGRAPHY TO STUDY THE LOCALIZATION OF GERMICIDES IN SKIN

60 citations , August 1969 in “British Journal of Dermatology”

Germicides mostly stay on the skin's surface, but some penetrate deeper depending on the product used.

research Targeted Delivery of Zinc Pyrithione to Skin Epithelia

14 citations , September 2021 in “International journal of molecular sciences”

Zinc pyrithione needs targeted delivery to the scalp for effective dandruff treatment.

research Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes

6 citations , August 2024 in “The Journal of Dermatology”

Ozenoxacin reduces sebum production, helping manage acne.

Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

research Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay

111 citations , February 2017 in “Antiviral research”

Researchers found several compounds that could potentially treat Zika virus.

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.

Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase

research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase

8 citations , June 1995 in “Helvetica Chimica Acta”

Compound 15a was effective in inhibiting 5α-reductase.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

research Comparison of the in vitro Demodex folliculorum killing activity of azelaic acid and permethrin

March 2022 in “Journal of health sciences and medicine”

Azelaic acid and permethrin both effectively kill the skin mite Demodex folliculorum in a lab setting.

research Minoxidil

June 2015 in “Reactions weekly”

research Minoxidil

December 2012 in “Reactions weekly”

Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2

research Antroquinonol Exerts Immunosuppressive Effect on CD8⁺ T Cell Proliferation and Activation to Resist Depigmentation Induced by H₂O₂

11 citations , January 2017 in “Oxidative medicine and cellular longevity”

Antroquinonol may help prevent skin depigmentation by suppressing certain immune cells.

research Clobetasol/minoxidil

February 2023 in “Reactions Weekly”

4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

research 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production

11 citations , March 2009 in “Bioorganic & Medicinal Chemistry Letters”

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

research The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial

38 citations , August 2015 in “Drug Design Development and Therapy”

Topical flutamide works as well as hydroquinone for melasma but needs more safety checks.

research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

3 citations , October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

research BindingDB Entry 50021519: Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

January 2025

Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

research 554 Repurposing a clinical antimalarial for the therapeutic induction of lethal ER stress targeting BRAF-kinase inhibitor-resistant malignant melanoma

April 2016 in “Journal of Investigative Dermatology”

Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.

research Direct access to novel chromeno-pyrimidine-N-oxides via tandem base catalyzed double nucleophilic addition/dehydration reaction

7 citations , March 2013 in “Tetrahedron Letters”

New method makes important drug ingredients more easily without needing extra purification steps.

research Efficacy of oral afoxolaner (NexGard®) against natural infestations with Heterodoxus spiniger (Phthiraptera: Boopiidae) in dogs under field conditions

July 2025 in “Veterinary Parasitology Regional Studies and Reports”

NexGard® and Frontline Combo® are both 100% effective at eliminating lice in dogs.

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