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Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.

Hexahydrobenzo[f]quinolines are effective at blocking the enzyme 5α-reductase.

RXR agonists may promote hair growth in humans.

The treatment temporarily improved symptoms of hyperandrogenism in adolescents.

Oral minoxidil and topical minoxidil 5% both effectively improve female-pattern hair loss with safe side effects.

Stopping finasteride improved seizure control, suggesting neurosteroids affect seizures and treatment.

Bicalutamide can reduce female pattern hair loss, especially in those with certain conditions, but has limited effects on other hair loss types.

Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.

Patients with rheumatoid arthritis using tofacitinib had more serious side effects than those with alopecia areata.

Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Ruxolitinib effectively and safely regrows hair in alopecia patients.

Goserelin injections can effectively manage hyperandrogenism symptoms in postmenopausal women who can't have surgery.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Dutasteride and finasteride have similar risk for osteoporosis and fractures in older men.

Lifestyle changes are more effective than medication for reducing type 2 diabetes risk.

5-alpha reductase inhibitors help treat prostate issues in aging men, but their role in cancer prevention is debated.

Combination therapy with fesoterodine and doxazosin improves bladder function and delays BPH progression.