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Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

The review suggests renaming two herbs to avoid confusion and recommends more research for safe use.

Confirming low-dose endocrine toxicities is difficult and requires more research.

Proper mineral supplementation in cow-calf operations prevents health issues and economic losses.

Vitamin E, alone or with yeast, helped reduce arsenic poisoning effects in young goats.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

High doses of TCB cause severe health issues in marmoset monkeys.

Low doses of date palm extract improve kidney function, but high doses may harm it.

The new FDA labeling rules provide more detailed drug safety information for pregnant and breastfeeding women, but more data is needed on the risks of many dermatologic drugs.

A new method effectively predicts estrogen-related health effects for early screening.

Minoxidil may harm male reproductive health by causing testicular damage and hormonal disruption.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Finasteride is a safe, effective treatment for hirsutism with fewer side effects.

EGFR-TKIs can cause significant skin, nail, and organ side effects.

Hormone treatments can help with women's skin and hair disorders, but they need careful monitoring and more research.

Minoxidil use during pregnancy may cause fetal harm.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

Metformin and thiazolidinediones are similarly effective for PCOS, but metformin is often preferred due to fewer side effects.

Mercury can disrupt sex hormones and cause reproductive issues.

Eclipta alba extract is generally safe with mild liver and kidney changes at high doses.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Spanish experts provided guidelines for treating skin side effects in cancer patients on new therapies, stressing early action and teamwork.

Anti-androgens are safe and effective for treating moderate to severe adult female acne.

Balanced selenium intake from wheat is crucial for preventing hair loss.

Many people in Fez-Meknes use potentially toxic plants for various health and cosmetic purposes, but more research is needed to ensure their safety.

Some medications and supplements can affect male fertility, with some improving and others harming sperm quality.

Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.

Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.