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SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

Nocturnal calcium infusions improved a boy's severe rickets without causing hair loss.

Lack of vitamin D receptor increases skin tumor risk by boosting hedgehog signaling.

CD73 may regulate hair growth and could be targeted for hair growth treatments.

Ritlecitinib is effective and safe for hair regrowth in Asian patients with alopecia areata.

Ritlecitinib may help treat alopecia areata by protecting hair follicles.

A new genetic variant causes trichothiodystrophy in two brothers, but their mother may carry it without showing symptoms.

Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.

Females with 5 alpha-reductase-2 deficiency have less body hair, no acne, normal fertility, and delayed menarche.

HMG-CoA reductase is crucial for skin wound healing by regulating keratinocyte growth and blood vessel formation.

SMR-2 and SMR-6 are much more toxic than retinoic acid, causing severe side effects.

A boy with chromosome 13q deletion syndrome developed eye cancer, a woman with breast cancer lost vision due to a rare side-effect of her treatment, a man's vision worsened after using a hair loss drug, and two rare disorders were discussed. Optical Coherence Tomography is useful for diagnosing and monitoring these conditions.

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Somatic BHD mutations are rare in Japanese renal tumors.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Removing REDD1 in mice increases skin fat by making fat cells larger and more numerous.

Retinoic acid causes gland formation instead of hair in mouse skin by altering epidermal and dermal interactions.

Early detection of specific VDR mutations is crucial for effective treatment and better dental outcomes in children with hereditary vitamin D–resistant rickets.

Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.

Ritlecitinib is effective long-term for treating alopecia areata in teens.

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.

Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.

Alopecia areata is an autoimmune disease that targets hair follicles.

Hairless protein can block vitamin D activation in skin cells.

Narrowband-UVB phototherapy successfully treated a rare case of Graham Little-Piccardi-Lassueur syndrome.

Patients with Discoid Lupus Erythematosus have lower vitamin D and antioxidant levels and higher oxidative stress.

Higher Claudin 3 levels in the blood are linked to more severe alopecia areata.

Ritlecitinib shows promise for hair regrowth in alopecia areata patients.