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GlossaryRetinol

vitamin A1 that promotes skin cell turnover and collagen

Retinol, also known as Vitamin A1, is a type of retinoid that plays a crucial role in maintaining healthy skin, vision, and immune function. It is commonly used in skincare products for its ability to promote cell turnover and collagen production, which can help reduce the appearance of fine lines, wrinkles, and acne.

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research Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectives

10 citations , September 2019 in “Experimental Eye Research”

The enzyme RDH12 plays a role in vision and retinal disease, with mutations leading to early onset visual loss and blindness, but the exact disease mechanism is unclear and there are no treatments yet.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations , November 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.

Serum Levels of Retinol-Binding Protein 4 and Adiponectin in Women with Polycystic Ovary Syndrome: Associations with Visceral Fat but No Evidence for Fat Mass-Independent Effects on Pathogenesis in This Condition

research Serum Levels of Retinol-Binding Protein 4 and Adiponectin in Women with Polycystic Ovary Syndrome: Associations with Visceral Fat But No Evidence for Fat Mass-Independent Effects on Pathogenesis in This Condition

44 citations , April 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.

research The Additive Effects of Minoxidil and Retinol on Human Hair Growth in Vitro

32 citations , January 2007 in “Biological & Pharmaceutical Bulletin”

Minoxidil and retinol together help hair grow.

research Lung Cancer Chemoprevention with Retinol Palmitate: Preliminary data from a randomized trial on stage la non small-cell lung cancer

18 citations , January 1988 in “Acta oncologica”

Retinol palmitate may reduce cancer relapses in early-stage lung cancer patients.

research Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands

16 citations , September 2019 in “Journal of biological chemistry/The Journal of biological chemistry”

Mice without certain skin enzymes have faster hair growth and bigger eye glands.

research [Low dosage retinol and L-cystine combination improve alopecia of the diffuse type following long-term oral administration].

16 citations , August 1989 in “PubMed”

Retinol and L-cystine improve diffuse hair loss without side effects.

Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

research Increased retinol‐binding protein (RBP) 4 and anti‐RBP4 antibody in alopecia areata

6 citations , June 2011 in “British Journal of Dermatology”

People with alopecia areata have higher levels of RBP4 protein and antibodies against it.

Possible Immunomodulating Effect of Retinol on Cytokine Secretion in Patients with Recurrent Furunculosis

research Possible Immunomodulating Effect of Retinol on Cytokines Secretion in Patients with Recurrent Furunculosis

4 citations , July 2017 in “Archivum Immunologiae et Therapiae Experimentalis”

Retinol may affect immune responses in people with frequent skin boils.

Inhibition of the Pro-Oxidant Effects of Benoxaprofen on Polymorphonuclear Leucocytes by Retinol Acetate In Vitro

research Inhibition of the pro-oxidant effects of benoxaprofen on poiymorpbonuclear leucocytes by retinol acetate in vitro

2 citations , July 1982 in “British Journal of Dermatology”

Retinol acetate can reduce the harmful effects of the drug benoxaprofen on white blood cells.

research Retinol-binding protein 4, leptin, and insulin resistance in idiopathic hirsutism and hirsute women with polycystic ovary syndrome

1 citations , May 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

Women with idiopathic hirsutism and PCOS have higher RBP4 levels, and PCOS is linked to greater insulin resistance; weight management may help both conditions.

research Actinic Hyperkeratosis Treated with Retinol Combined with a Polylysine Biovector: A Case Report

September 2025

Retinol with polylysine cleared scalp skin growths in 21 days without side effects.

research Co-delivering Retinol and Niacinamide via Liposomes: Enhanced Stability, Efficient Skin Permeation, and Improved Anti-Aging/Skin-Brightening Efficacy

August 2025

The new delivery system makes retinol and niacinamide more stable and effective for anti-aging and skin-brightening.

research 0870 Improving the stability of retinol: Overcoming obstacles through solid lipid particle technology

July 2025 in “Journal of Investigative Dermatology”

Solid Lipid Particle technology makes retinol more stable, effective, and gentle on the skin.

research Actinic Hyperkeratosis Treated with Retinol Combined with A Polylysine Biovector: A Case Report

January 2025 in “ARC Journal of Clinical Case Reports”

Encapsulated retinol may effectively treat actinic keratosis without side effects.

research Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition

April 2024 in “Communications biology”

Enzymes involved in Vitamin A metabolism affect hair growth and type in mice.

research Serum level of retinol-binding protein 4 in alopecia areata: relation with recurrence and severity

January 2022 in “Menoufia Medical Journal /Menoufia Medical Journal”

Higher levels of retinol-binding protein 4 are found in people with alopecia areata, but these levels don't relate to how severe the condition is.

research 182 Retinol remarkably effective in reducing neck wrinkles

September 2019 in “Journal of Investigative Dermatology”

Retinol significantly reduces neck wrinkles.

research Assessment of retinol-binding protein 4 in patients with alopecia areata and androgenetic alopecia

September 2016 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

Higher RBP4 levels found in people with two types of hair loss.

Cellular Retinol-Binding Protein-1 Expression Increases with Clinical Severity of Alopecia Areata

research Cellular retinol‐binding protein‐1 expression increases with increasing clinical severity of alopecia areata

2 citations , December 2018 in “Journal of cosmetic dermatology”

Higher CRBP1 levels are linked to more severe alopecia areata.

research 569 Application of 3D scaffold free dermal spheroids to investigate retinol and retinol alternatives mechanism of action on extracellular matrix

July 2024 in “Journal of Investigative Dermatology”

research Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

140 citations , December 2017 in “Journal of Controlled Release”

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

research Cytochrome P450: A Target for Drug Development for Skin Diseases

115 citations , August 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

research Glandular metaplasia of hair follicles and other responses to vitamin A excess in cultures of rodent skin

77 citations , April 1968 in “Development”

Excess vitamin A can cause hair follicles to change into gland-like structures.

research The skin as an endocrine organ

75 citations , September 2009 in “Dermato-endocrinology”

The skin produces and processes hormones, affecting both local and overall body functions.

research Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation

56 citations , November 2003 in “Journal of Investigative Dermatology”

MMP-19 may worsen skin diseases by affecting skin growth and inflammation.

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

48 citations , March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Retinoic acid production and signaling in hair follicles are regulated by location and timing, affecting hair growth and cycling.

research Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

47 citations , September 2023 in “Pharmacological Reports”

Vitamins A, B3, C, D, and E can improve skin health and immunity.

research Penetration and Local Effect of Vitamin A on the Skin of the Guinea Pig.,

45 citations , August 1954 in “Experimental Biology and Medicine”

Vitamin A penetrates guinea pig skin quickly in alcohol, affects skin thickness, but doesn't impact hair growth.

research Safety of High-Dose Vitamin A

39 citations , January 1991 in “Oncology”

High-dose vitamin A was safe and well-tolerated in a lung cancer treatment study.