research Tumour regression predicts higher risk of sentinel node involvement in thin cutaneous melanomas
Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.
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research A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride
Both drugs lower DHT levels, with GI198745 being more effective.
research Delayed-onset pachyonychia congenita caused by a novel mutation in the V2 domain of keratin 6b
A new mutation in the K6b gene caused a girl's late-appearing nail condition.
research Malarone® induced pancreatitis and alopecia in a dog: a case report
Malarone® caused pancreatitis and hair loss in a dog for the first time.
research Medications
Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.
research DHEA : why, when, and how much ? D’après la conférence de Bruno Allolio (Wuerzburg), 50e Journées internationales d’endocrinologie clinique Henri-Pierre KLOTZ, septembre 2007
DHEA supplementation may improve quality of life, neuropsychological functions, and sexual satisfaction in individuals with adrenal insufficiency, but more research is needed to confirm its safety and effectiveness.
research Oral Retinoids in Dermatology
Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
research Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism
High doses of finasteride cause cell growth and tumors in mice.
research Baiting Proteins with C60
C60 fullerenes can alter protein function and may help develop new disease inhibitors.
research Treatment of Hair Loss
Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
research Pathobiology of chemotherapy-induced hair loss
Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.
research Effects of Flutamide and Finasteride on Rat Testicular Descent
Androgens, like testosterone, are crucial for early testicular descent in rats.
research Dermatologic Manifestations of Polycystic Ovary Syndrome
Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.
research Influence of spironolactone treatment on endothelial function in non-obese women with polycystic ovary syndrome
Spironolactone improved blood vessel function and cholesterol levels in non-obese women with PCOS.
research Selective non-steroidal inhibitors of 5α-reductase type 1
Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.
research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.
research Chemotherapy-Induced Anagen Effluvium: Diffuse or Patterned?
Chemotherapy can cause rapid, extensive hair loss, with patterns varying between individuals.
research Minoxidil opens mitochondrial KATP channels and confers cardioprotection
Minoxidil protects heart and improves recovery.
research Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model
Korean Red Ginseng may protect against hair loss caused by chemotherapy.
research Leucaena Leucocephala a Nutrition Profile
Leucaena leucocephala is nutritious but needs careful processing to remove toxins.
research Effects of Minoxidil on Cultured Human Skin Fibroblasts
Minoxidil slows down skin cell growth and may help treat scars and skin conditions.
research An antimicrobial microneedle patch promotes functional healing of infected wounds through controlled release of adipose tissue-derived apoptotic vesicles
The microneedle patch helps heal infected wounds quickly and without scars.
research Adverse cutaneous effects of psychotropic medications
Psychotropic medications can cause skin problems, including serious conditions, and patients should be monitored closely.
research The biology and clinical application of systemic glucocorticoids
Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.
research Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern?
5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.
research Abemaciclib-Associated Skin, Hair, and Nail Toxicities: A Case Report
Abemaciclib can cause skin, hair, and nail problems, leading some patients to stop using it.
research Scarring Alopecia: Cutting-Edge Approaches
Early diagnosis and new treatments are crucial to prevent permanent hair loss in scarring alopecia.
research TOC
Understanding drug effects and careful monitoring are crucial for safe and effective dermatology treatments.
research Clinical applications of antiandrogens
Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.
research A population‐based nested case–control study: the use of 5‐alpha‐reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia
Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.