127 citations
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January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
120 citations
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November 2014 in “Biological Reviews” The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.
103 citations
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December 2021 in “Journal of biological rhythms” Shift work disrupts the body's natural clock, leading to health problems.
91 citations
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August 2014 in “Development” The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.
84 citations
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December 2017 in “EMBO Reports” Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.
77 citations
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June 2007 in “PLoS ONE” Birds can regenerate inner ear cells using specific gene pathways, unlike mammals.
64 citations
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August 2019 in “Circulation” ADT, especially enzalutamide, may increase the risk of heart rhythm problems and sudden death in men.
59 citations
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February 2012 in “Journal of Dermatological Science” Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.
55 citations
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March 2010 in “Aging” Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.
52 citations
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July 2011 in “PubMed” TRPS1 is crucial for bone, kidney, and hair follicle development.
51 citations
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January 2004 in “Domestic animal endocrinology” Melatonin implants and long daylight hours alter the timing of hormone release and hair growth in mouflon sheep.
49 citations
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April 2016 in “International journal of molecular sciences” Shift nurses show altered body temperature and stress hormone levels, suggesting their body clocks adjust to irregular schedules.
47 citations
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September 2013 in “Aaps Pharmscitech” Improved hair loss treatment using special particles and surfactants.
38 citations
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June 2017 in “The Journal of Dermatology” Aging in hair follicle stem cells leads to hair graying, thinning, and loss.
35 citations
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November 2022 in “The Journal of Dermatology” Alopecia areata is becoming more common in Japan, with a need for better treatments, especially for severe and pediatric cases.
31 citations
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January 2011 in “Dermato-endocrinology” Melatonin protects skin against UV damage by regulating various cellular processes.
28 citations
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May 2017 in “Molecular ecology” Researchers found genes that control hair color and growth change before the visible coat color changes in snowshoe hares.
27 citations
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March 2018 in “Allergy and asthma proceedings” People with alopecia areata often have higher rates of allergies and autoimmune diseases.
23 citations
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July 2021 in “Life” Blue light can help treat skin conditions like eczema and acne without major side effects.
23 citations
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January 2019 in “Journal of wildlife diseases” Boreal caribou in northeastern British Columbia have significant health issues, including infections, tick infestations, and mineral deficiencies.
19 citations
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August 2024 in “Journal of Translational Medicine” Epidermal stem cells are vital for skin healing and have potential for treating skin disorders.
19 citations
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April 2018 in “International Journal of Dermatology” People with Lichen Planopilaris are more likely to have autoimmune diseases, especially Systemic Lupus Erythematosus, and less likely to have diabetes and some other common conditions.
19 citations
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August 2007 in “Seminars in Plastic Surgery” Newer skin resurfacing lasers reduce damage and scarring, with some approved for safe use and minimal side effects.
18 citations
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March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
18 citations
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January 2020 in “Ecology and evolution” Genes related to pigmentation, body rhythms, and behavior change during hares' seasonal coat color transition, with a common genetic mechanism in two hare species.
18 citations
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March 2015 in “Journal of Investigative Dermatology” Silencing certain circadian clock genes increases skin pigmentation.
17 citations
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January 2015 in “MedChemComm” New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.
16 citations
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September 2004 in “Pediatric dermatology” Children and adolescents with allergies tend to have longer eyelashes.
15 citations
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January 2023 in “Journal of Translational Autoimmunity” Melatonin may help treat skin conditions.
15 citations
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October 2012 in “Journal of circadian rhythms” RNA from horse hair follicles can track circadian rhythms non-invasively.