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research Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess

40 citations , February 2005 in “Fertility and Sterility”

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

research Molecular cloning and characterization analysis of LEF-1 gene from Inner Mongolia Cashmere Goat

1 citations , October 2010 in “2010 3rd International Conference on Biomedical Engineering and Informatics”

The LEF-1 gene in cashmere goats was successfully cloned and analyzed, showing potential for improving cashmere production.

research Association study reveals a susceptibility locus with male pattern baldness in the Han Chinese population

September 2024 in “Frontiers in Genetics”

A specific genetic marker is linked to male pattern baldness in Han Chinese men.

research Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression

47 citations , February 2014 in “Journal of Cutaneous Pathology”

Matrical tumors share a common growth mechanism involving the Wnt pathway and consistent PHLDA1 expression.

research Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.

11 citations , May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

research Haplotype analysis ofVEGFgene polymorphisms in polycystic ovary syndrome

4 citations , April 2019 in “Gynecological Endocrinology”

Certain gene variations are found in people with polycystic ovary syndrome.

research Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness

24 citations , April 2017 in “Oncology Reports”

The hair keratin gene KRT81 is found in both normal and breast cancer cells and helps them invade surrounding tissues.

research Mutations in Sterol O-Acyltransferase 1 (Soat1) Result in Hair Interior Defects in AKR/J Mice

23 citations , June 2010 in “Journal of Investigative Dermatology”

A mutation in the Soat1 gene causes hair structure defects and other health issues in AKR/J mice.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Visceral and Subcutaneous Adipose Tissues of Patients with Polycystic Ovary Syndrome Is Associated with Adiposity

research Expression of 11β-hydroxysteroid dehydrogenase type 1 in visceral and subcutaneous adipose tissues of patients with polycystic ovary syndrome is associated with adiposity

18 citations , December 2010 in “The Journal of Steroid Biochemistry and Molecular Biology”

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

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