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research A novel hairless highly immunodeficient mice model optimized for in vivo imaging

April 2026 in “Laboratory Animal Research”

Researchers have developed a novel Hairless Rag2/Jak3 KO mice model, known as Hairless R/J mice, optimized for in vivo imaging. These mice are hairless and lack T, B, and NK cell phenotypes, making them ideal for non-invasive observation of molecular behavior. Compared to traditional Nude mice, Hairless R/J mice have thinner skin and superior optical properties, enhancing imaging capabilities. The model was tested using green fluorescent beads and mCherry-expressing human cholangiocarcinoma cells, as well as Ihara cells for live imaging of tumor growth. This new model is expected to be a valuable tool for noninvasive tumor monitoring and evaluating anticancer therapies.

research lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions

4 citations , August 2022 in “Cells”

lncRNA2919 slows down rabbit hair growth by stopping cell growth and causing cell death.

research The Near-Naked Hairless (Hr) Mutation Disrupts Hair Formation but Is Not Due to a Mutation in the Hairless Coding Region

8 citations , March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

The near-naked hairless mutation causes hair loss but is not due to a mutation in the hairless gene itself.

research A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.

46 citations , May 1995 in “Proceedings of the National Academy of Sciences”

A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.

research Mitogen‐regulated protein/proliferin mRNA induction following single applications of tumor promoters to murine skin

May 2005 in “Molecular Carcinogenesis”

mrp/plf-mRNA can indicate tumor-promoting effects in skin.

research A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue

31 citations , April 2004 in “Journal of Investigative Dermatology”

A new mouse gene, Keratin 17n, is mainly found in nail tissue and may explain why mice without Keratin 17 don't have nail issues.

research Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer

December 2024 in “European journal of medical research”

research Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB

54 citations , June 2008 in “Planta Medica”

Hinokitiol may help treat hair loss by reducing inflammation and promoting hair growth.

research Butyrophilin-like 2 (BTNL2) to the Rescue: controlling autoaggressive dermal gamma delta (GD) T lymphocytes in human hair follicles (HFs) 3747

November 2025 in “The Journal of Immunology”

BTNL2 helps protect hair follicles from immune attacks, which could aid in treating alopecia areata.

research 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration

April 2019 in “Journal of Investigative Dermatology”

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

research Downregulation of nuclear factor-kappaB activation in human keratinocytes by melanogenesis inhibitors

May 2004 in “International Journal of Cosmetic Science”

Melanogenesis inhibitors like kojic acid and niacinamide can reduce inflammation and pigment production in skin cells.

research c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer

4 citations , January 2021 in “Journal of Clinical Medical Research”

c-Kit is important for heart regeneration and cancer development.

research Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

February 2013

Activating cannabinoid receptor 1 may help manage psoriasis by reducing certain keratins.

research A study of phenotypic correlation with the genotypic status of HTM regions of KRTHB6 and KRTHB1 genes in monilethrix families of Indian origin

4 citations , October 2003 in “Annales de Génétique”

A specific gene mutation causes different hair defects in Indian monilethrix families.

research A novel mutation in the FERMT1 gene in a Spanish family with Kindler’s syndrome

8 citations , December 2009 in “Journal of The European Academy of Dermatology and Venereology”

Researchers found a new mutation in the FERMT1 gene in a Spanish family with Kindler syndrome.

research 547 CDK9 Kinase Activation in Association with AFF1-SEC Initiate Epidermal Progenitor differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

Special Collection on Inward Rectifying Potassium Channels

research Special collection on inward rectifying K⁺ channels

3 citations , January 2023 in “American journal of physiology. Cell physiology”

Inward rectifier potassium channels are important in many body functions and diseases, and could be potential drug targets.

research Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (Hr^Hp) Mice

11 citations , January 2015 in “Journal of cellular physiology”

HR protein causes abnormal hair cycles by increasing Tgf-β2 and reducing miR-31.

research Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway

8 citations , June 2023 in “Acta Biochimica et Biophysica Sinica”

rRSPO1 protein boosts hair growth by activating a key signaling pathway.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research Krtap11-1, a hair keratin-associated protein, as a possible crucial element for the physical properties of hair shafts

38 citations , January 2014 in “Journal of Dermatological Science”

Krtap11-1 is important for hair strength and structure.

research A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type

60 citations , March 2006 in “Journal of Medical Genetics”

A mutation in the KRTHB5 gene causes hair and nail issues.

research A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11

49 citations , October 1989 in “Genomics”

Type I keratin genes are closely linked to the rex locus on mouse chromosome 11, affecting hair development.

research Exploring differential gene expression and biomarker potential in systemic lupus erythematosus: a retrospective study

September 2025 in “PeerJ”

FCER1A and RGS1 may help diagnose and treat systemic lupus erythematosus.

research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

Blocking certain proteins can reduce skin inflammation caused by cancer treatment.

research Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease

33 citations , January 2018 in “Blood”

Ruxolitinib helps protect skin stem cells and keeps skin healthy in mice with skin GVHD.

research Differential expression of keratin 19 in normal human epithelial tissues revealed by monospecific monoclonal antibodies

159 citations , October 1986 in “The Histochemical Journal”

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