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research Investigating Potential Causal Relationships Between Plasma Protein Ratios and Alopecia Areata: A Bidirectional Mendelian Randomization Study

September 2025 in “British Journal of Hospital Medicine”

This study investigated the causal relationships between plasma protein ratios (PPRs) and alopecia areata (AA) using data from over 54,000 individuals in the UK Biobank and 862 AA cases from FinnGen. The analysis identified that increased ratios of agrin/heparan sulfate proteoglycan 2 (AGRN/HSPG2) and 2,4-dienoyl-CoA reductase 1/FK506-binding protein 1B (DECR1/FKBP1B) are significantly associated with a higher risk of AA, with odds ratios of 1.448 and 1.658, respectively. Reverse Mendelian randomization analysis showed no significant causal effects of AA on these PPRs. The findings suggest these PPRs could be important in understanding and managing AA.

Unusual Systemic Lupus Erythematosus/Sjogren's Syndrome Phenotype in a Patient with a TNFAIP3 Gene Mutation

research SAT0200 UNUSUAL SYSTEMIC LUPUS ERYTHEMATOSUS/SJOEGREN'S SYNDROME PHENOTYPE IN A PATIENT WITH A TNFAIP3 GENE MUTATION

June 2019

A TNFAIP3 gene mutation can cause unusual and varied symptoms of lupus and Sjogren's syndrome.

research Identification of compound heterozygous mutations in AP1B1 leading to the newly described recessive keratitis–ichthyosis–deafness (KIDAR) syndrome

11 citations , January 2021 in “British Journal of Dermatology”

Mutations in the AP1B1 gene cause a new syndrome with skin, hearing, and developmental issues.

research Ginsenosides Rb₁ and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles

15 citations , September 2012 in “PTR. Phytotherapy research/Phytotherapy research”

Ginsenosides Rb₁ and Rd may help prevent hair loss by promoting hair cell growth.

research Retinol-binding protein 4, leptin, and insulin resistance in idiopathic hirsutism and hirsute women with polycystic ovary syndrome

1 citations , May 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

Women with idiopathic hirsutism and PCOS have higher RBP4 levels, and PCOS is linked to greater insulin resistance; weight management may help both conditions.

research Intermittent Low-dose Ritlecitinib in Refractory Paediatric Alopecia Areata: A Case Report with Therapeutic Implications

June 2025 in “Acta Dermato Venereologica”

Low-dose Ritlecitinib may help children with stubborn Alopecia Areata.

research Integrated Transcriptome Analysis of lncRNA, miRNA, and mRNA Reveals key Regulatory Modules for Polycystic Ovary Syndrome

2 citations , October 2024 in “Phenomics”

research Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin

34 citations , August 2018 in “Cancer research”

Fixing DNA errors is crucial to prevent skin cancer.

research Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin

10 citations , November 2015 in “Experimental Dermatology”

Skin RAGE levels are linked to inflammation and cell death.

Anticoagulant-Free Preparation of Autologous Platelet-Rich Plasma (PRP) / Fluid Platelet-Rich Fibrin (f-PRF): A Pre-Clinical Comparative Performance Study

research Anticoagulant-free preparation of autologous platelet-rich plasma (PRP) / fluid platelet-rich fibrin (f-PRF): a pre-clinical comparative performance study

March 2026 in “Frontiers in Pharmacology”

Exprecell™ is as effective as traditional methods but produces more f-PRF and is simpler to use.

research RNase L represses hair follicle regeneration through altered innate immune signaling

February 2025 in “Journal of Clinical Investigation”

RNase L hinders hair growth by altering immune signals.

research Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis

46 citations , November 2004 in “Lipids”

PPARs help regulate skin health and could be used to treat skin disorders.

research Comprehensive transcriptome profiling between balding and non-balding scalp of Female pattern hair loss in Asian

February 2024 in “Research Square (Research Square)”

The research suggests that SFRP2 and PTGDS proteins might be indicators of female pattern hair loss and could contribute to hair loss.

research The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata

9 citations , May 2019 in “Medicine”

The C-allele and CC-genotype in the PTPN22 gene lower the risk of alopecia areata.

research Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles and Dermal Papilla Cells

November 2021 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Resveratrol may help promote hair growth and treat hair loss.

research Spermidine/spermine-N¹-acetyltransferase: a key metabolic regulator

305 citations , March 2008 in “AJP Endocrinology and Metabolism”

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

research Male pattern hair loss - rh79g

December 2025 in “ILDS-DEV”

Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

research Rat steroid 5α-reductase kinetic characteristics: Extreme pH-dependency of the type II isozyme in prostate and epididymis homogenates

13 citations , August 1995 in “The Journal of Steroid Biochemistry and Molecular Biology”

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

research Gpr54 deletion accelerates hair cycle and hair regeneration

1 citations , November 2024 in “EMBO Reports”

Deleting Gpr54 speeds up hair growth and regeneration.

research Signaling from keratins

May 2006 in “The Journal of Cell Biology”

Keratin 17 is crucial for cell growth in wound healing by aiding protein synthesis.

research 09-P004 Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signaling

August 2009 in “Mechanisms of Development”

research 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis

1 citations , July 2024 in “Journal of Investigative Dermatology”

TAK-279 effectively reduces psoriasis symptoms and is safe.

research Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

79 citations , October 2003 in “PubMed”

Overexpression of PKCepsilon leads to increased TNFalpha, promoting metastatic squamous cell carcinoma in mice.

research Generation of Genetically Modified Rats Using CRISPR/Cas9 Genome-Editing System to Reveal Novel Vitamin D Actions

January 2021 in “Medical Research Archives”

Genetically modified rats help reveal how vitamin D affects bone and skin health.

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome (APECED) Due to AIRE T16M Mutation in a Consanguineous Greek Girl

research Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome (APECED) due to AIRET16M mutation in a consanguineous Greek girl

6 citations , January 2011 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”

An 11-year-old Greek girl was diagnosed with a rare genetic disorder, highlighting the importance of genetic testing and family history.

research Autoimmune polyendocrine syndrome type 1: an Italian survey on 158 patients

31 citations , May 2021 in “Journal of endocrinological investigation”

APS-1 in Italy shows diverse AIRE mutations and various autoimmune issues.

Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision Between Stem Cell Maintenance and Differentiation

research Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation

1 citations , December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Sox9 levels in brain stem cells affect whether they stay as stem cells or become neurons.