research Testicular Steroidogenesis
Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.
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research Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells
Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
research The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism
Finasteride effectively reduces hair growth in women with polycystic ovary syndrome or idiopathic hirsutism.
research The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways
Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.
research I‐Ascorbic acid 2‐phosphate represses the dihydrotestosterone‐induced dickkopf‐1 expression in human balding dermal papilla cells
Vitamin C derivative reduces hair loss-related protein in cells.
research Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
Genetic variations affect dutasteride treatment response for male pattern hair loss.
research Steroidogenesis in steroid related cancers
Steroid-producing capabilities in certain cancers may contribute to treatment resistance.
research Androgen Biosynthesis and Gene Defects
Gene mutations can cause problems in male genital development.
research Treatment of Hair Loss
Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
research Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp
Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
research Androgens and hair growth
Androgens can both increase and decrease hair growth in different parts of the body.
research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes
A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
research Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
Finasteride effectively blocks enzyme causing male pattern baldness.
research Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla
Male pattern baldness involves hormones and cell signals affecting hair growth.
research 5α‐Reductase Isozymes and Androgen Actions in the Prostate
5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.
research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase
New compounds called benzoquinolinones may treat conditions linked to excess DHT.
research Finasteride: A slow-binding 5.alpha.-reductase inhibitor
Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
research Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth
Wnt1a-conditioned medium from stem cells helps activate cells important for hair growth and can promote hair regrowth.
research Male pattern hair loss: current understanding
Genetics and hormones cause hair loss; finasteride treats it safely.
research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells
High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.
research 46,XY DSD due to impaired androgen production
Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.
research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.
LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.
research Finasteride for female androgenetic alopecia
Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.
research The genetics of androgenetic alopecia
Genes and hormones cause hair loss, with four genes contributing equally.
research The effect of spironolactone on genital skin 5α-reductase activity
Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.
research Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles
Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.
research Promotion of Hair Growth byRosmarinus officinalisLeaf Extract
Rosemary leaf extract may be an effective natural treatment for hair growth and male pattern baldness.
research Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia
Androgens prevent hair growth by changing Wnt signals in cells.
research Ketoconazole Therapy for Women with Acne and/or Hirsutism
Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.
research Regulation of masculinization: androgen signalling for external genitalia development
Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.