research Effective holistic characterization of small molecule effects using heterogeneous biological networks
Integrating biological networks improves drug repurposing and ADR prediction.
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90-120 / 1000+ resultsresearch Evidence based medicine: a movement in crisis?
Evidence-based medicine needs improvement to better tailor treatments to individual patients.
research Management of psychiatric disorders with HIV and dermatological disorders
The conclusion is that careful management of both psychiatric and skin conditions is crucial for HIV patients, using medication and interdisciplinary approaches.
research Risk of Poor Glycemic Control in Tamsulosin Versus Finasteride Users with Type 2 Diabetes Mellitus
Tamsulosin and finasteride have similar effects on blood sugar control in men with type 2 diabetes.
research Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks
Extracellular vesicles could offer precise treatments for psychiatric conditions by targeting brain networks.
research Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers
New nanocarriers improve drug delivery for disease treatment.
research State of the Science Burn Research: Burns in the Elderly
Burn care for the elderly needs improvement, with more research and specific guidelines required.
research Trichotillomania as a Manifestation of Dementia
Trichotillomania in dementia may be better treated with dopamine blockers like quetiapine than with SSRIs.
research Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression
Tadalafil and Finasteride may help treat aggressive melanoma.
research Obesity in Adults: Position Statement of Polish Association for the Study on Obesity, Polish Association of Endocrinology, Polish Association of Cardiodiabetology, Polish Psychiatric Association, Section of Metabolic and Bariatric Surgery of the Association of Polish Surgeons, and the College of Family Physicians in Poland
The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.
research Cancer prevalence after exposure to Wnt-activating drugs: a systematic review
Wnt-activating drugs generally do not increase cancer risk.
research European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity
Test thyroid function in all obese patients and prioritize weight loss for hormonal balance.
research Validation of the follicular and ovarian thresholds by an 18-MHz ultrasound imaging in polycystic ovary syndrome: a pilot cutoff for North African patients
New ultrasound criteria for diagnosing PCOS in North African patients were successfully established.
research A Review of the Characteristics of Clinical Trials and Potential Medications for Alcohol Dependence: Data Analysis from ClinicalTrials.gov
No medications for alcohol dependence have been approved for marketing yet.
research Use of combined oral contraceptives and risk of venous thromboembolism in young women: a nested case–control analysis using German claims data
Some birth control pills increase young women's risk of blood clots more than others.
research Pharmacovigilance-based drug repurposing: searching for putative drugs with hypohidrosis or anhidrosis adverse events for use against hyperhidrosis
Certain existing drugs, like glycopyrronium and botulinum toxin type A, may help treat excessive sweating.
research Medicinal Chemistry of Drugs with N-Oxide Functionalities
N-oxides are important in medicine for improving drug properties and targeting.
research Game Changers: Blockbuster Small-Molecule Drugs Approved by the FDA in 2024
In 2024, the FDA approved 27 innovative small-molecule drugs, with many offering significant treatment improvements.
research Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations
Nanoformulations improve drug delivery through the skin, reducing side effects and enhancing effectiveness.
research Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases
Nanoemulgels could effectively treat skin diseases and may replace or complement current therapies.
research Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19
A standardized drug development platform is essential for efficient and effective drug repurposing, especially during pandemics.
research Canadian Expert Recommendations on Safety Overview and Toxicity Management Strategies for Sacituzumab Govitecan Based on Use in Metastatic Triple-Negative Breast Cancer
Sacituzumab Govitecan is effective for certain breast cancers but requires careful management of side effects.
research Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats
Deleting the EDAR gene in Cashmere goats affects genes and proteins related to hair growth.
research Valorization of Unconventional Hair Waste: Unlocking Opportunities in Materials and Chemical Engineering
Human hair waste can be valuable in engineering and materials due to its unique properties.
research Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development
Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.
research Recent advances in neuropeptide-related omics and gene editing: Spotlight on NPY and somatostatin and their roles in growth and food intake of fish
New tools show that in fish, NPY increases feeding and somatostatin decreases it.
research Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair
Managing stress and nerve activity can help treat segmental vitiligo and white hair.
research Long-acting microneedle formulations
Microneedles are promising for long-acting drug delivery and can improve patient compliance, but more data is needed to confirm their effectiveness.
research A Gender Hypothesis of sex disparities in adverse drug events
Gendered social factors, not just biology, contribute to sex differences in adverse drug events.
research Impacts of Anabolic-androgenic steroid supplementation on female health and offspring: Mechanisms, side effects, and medical perspectives
Anabolic-androgenic steroids can harm women's health and their offspring.