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research Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase

11 citations , January 2000 in “The Journal of Steroid Biochemistry and Molecular Biology”

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

research Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

11 citations , September 1997 in “Archives of Dermatology”

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

research Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.

11 citations , May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

The Effects of Finasteride on Hair Growth, Hair Cycle Stage, and Serum Testosterone and Dihydrotestosterone in Adult Male and Female Stumptail Macaques

research The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides).

11 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.

research Comparative Efficacy and Safety of Janus Kinase Inhibitors Used in Alopecia Areata: A Systematic Review and Meta-analysis

10 citations , January 2023 in “Acta dermato-venereologica”

Baricitinib and deuruxolitinib are effective for treating alopecia areata, but their efficacy depends on the dose.

research Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

10 citations , March 2022 in “Communications biology”

A new non-invasive method can analyze skin mRNA to understand skin diseases better.

research The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis

10 citations , December 2021 in “Frontiers in cell and developmental biology”

Glypican-1 is important for blood vessel growth in hair follicles and could help treat hair loss.

research Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin

10 citations , November 2018 in “Genetics in medicine”

Lack of cystatin M/E causes thin hair and dry skin.

Transcriptome Sequencing and Identification of Cytochrome P450 Monooxygenases Involved in the Biosynthesis of Maslinic Acid and Corosolic Acid in Avicennia Marina

research Transcriptome sequencing and identification of cytochrome P450 monooxygenases involved in the biosynthesis of maslinic acid and corosolic acid in Avicennia marina

10 citations , October 2018 in “Plant Biotechnology”

Researchers found two enzymes in Avicennia marina that help produce maslinic acid and corosolic acid, which have medicinal benefits.

research Polyphenols as novel treatment options for dermatological diseases: A systematic review of clinical trials

10 citations , November 2014 in “Journal of Dermatological Treatment”

Polyphenols may help treat skin conditions like warts, hair loss, acne, and dark spots, but more research is needed.

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