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Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors and Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

research Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

9 citations , May 2021 in “Molecules”

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

research Editor's evaluation: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma

August 2021

Keratinocytes can reduce the survival of certain melanoma cells, suggesting new therapy paths.

research Can we identify a post‐Serenoa syndrome (PSS)? A case series on sexual and psychiatric side effects of Serenoa repens

January 2026 in “British Journal of Clinical Pharmacology”

Serenoa repens may cause long-lasting sexual and psychiatric side effects.

research Modification of hair dysplasia curve by radioprotectors containg sulfur as a function of the x-ray dose.

2 citations , January 1968 in “PubMed”

Sulfur-containing radioprotectors can protect hair from X-ray damage if given before exposure but worsen damage if given after.

research Serenoa repens induced erectile dysfunction: Underdiagnosis and phytovigilance

1 citations , November 2021 in “British Journal of Clinical Pharmacology”

Saw palmetto may cause erectile dysfunction and needs better safety monitoring.

research Toxicity profile of antibody-drug conjugates in breast cancer: practical considerations

15 citations , July 2023 in “EClinicalMedicine”

ADCs can effectively treat breast cancer but may cause side effects like nausea and hair loss.

research Selenium Disulfide Shampoo

12 citations , July 1964 in “Archives of Dermatology”

Selenium sulfide shampoo doesn't affect hair growth or rest phases.

research Enhancing 1α-Hydroxylase Activity with the 25-Hydroxyvitamin D-1α-Hydroxylase Gene in Cultured Human Keratinocytes and Mouse Skin

18 citations , June 2001 in “Journal of Investigative Dermatology”

Adding a specific gene to skin cells can help treat skin disorders like psoriasis.

Selective Inhibition of 5α-Reductase and Preservation of Aromatase in Hair Transplantation

research Inibição seletiva da 5α-redutase e preservação da aromatase no transplante capilar

February 2026 in “Revista Eletrônica Polidisciplinar Voos.”

A balanced approach using dutasteride and Serenoa repens can improve hair transplant success by protecting follicles and minimizing side effects.

Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

research Development of a new therapeutic approach based on peptide nanoparticles delivering CRISPR-Cas9 for the specific targeting of KRAS mutations

September 2023 in “HAL (Le Centre pour la Communication Scientifique Directe)”

Peptide nanoparticles can effectively deliver CRISPR-Cas9 to target KRAS mutations in cancer.

research Epidermal and hair follicle trans glutaminases and crosslinking in skin

54 citations , January 1984 in “Molecular and Cellular Biochemistry”

Innovative Sequence of Docetaxel–Gemcitabine Based on Preclinical Data in the Treatment of Advanced Non-Small Cell Lung Cancer: A Phase I Study

research Innovative sequence of docetaxel–gemcitabine based on preclinical data in the treatment of advanced non small cell lung cancer: a phase I study

3 citations , February 2005 in “Lung Cancer”

The new chemotherapy combination for advanced lung cancer showed a 35.7% response rate but caused significant side effects.

The Efficacy and Safety of Anlotinib Plus Etoposide with Cisplatin/Carboplatin in the First-Line Treatment of Lung Cancer: A Phase II Clinical Study

research The Efficacy and Safety of Anlotinib Plus Etoposide with Cisplatin/Carboplatin in the First-Line Treatment of Lung Cancer: A Phase II Clinical Study

5 citations , January 2024 in “Journal of Cancer”

The treatment combination is effective and generally safe for lung cancer.

research Dramatic Clinical Improvement With Biotin Mega‐Dose Therapy in a Neonate With Holocarboxylase Synthetase Deficiency

2 citations , August 2024 in “Molecular Genetics & Genomic Medicine”

Biotin mega-dose therapy led to dramatic improvement in a newborn with a rare metabolic disorder.

research Preventing and modifying the aging process.

December 1989 in “PubMed”

research Holding Solutions, Conditions, and Additives to Optimize Hair Follicle Viability and Function

September 2017

research Drug Repurposing of Voglibose, a Diabetes Medication for Skin Health

4 citations , February 2025 in “Pharmaceuticals”

Voglibose may help treat skin hyperpigmentation safely.

Individual Article: USCOM V: A Practical Algorithm for the Prevention and Treatment of Cutaneous Side Effects of Hormonal Cancer Therapy

research INDIVIDUAL ARTICLE: USCOM V: A Practical Algorithm for the Prevention and Treatment of Cutaneous Side Effects of Hormonal Cancer Therapy

March 2025 in “Journal of Drugs in Dermatology”

A new method helps manage skin side effects from hormonal cancer therapy, improving patient care.

The Editor's Choice: Summary of Studies on Skin and Hair Conditions

research The Editor's Choice

June 2018 in “Journal of Dermatological Science”

UV radiation may cause DNA changes in skin, certain UVB therapy helps psoriasis, a new gene mutation is linked to mild piebaldism, different immune cells affect psoriasis, a drug promotes hair growth, and some cancer drugs could treat skin barrier issues.

research Curly : a new hair defect mutation in the SELH/bc mouse strain

January 2009

The curly mutation in SELH/Bc mice affects hair and may help study human genetic disorders.

research Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermisin vivo

2 citations , November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Mutant stem cells adapt their metabolism differently to outcompete normal cells in the skin.

The VEGF +405 G>C 5' Untranslated Region Polymorphism and Risk of PCOS: A Study in South Indian Women

research The VEGF +405 G>C 5' untranslated region polymorphism and risk of PCOS: a study in the South Indian Women

28 citations , August 2014 in “Journal of Assisted Reproduction and Genetics”

The VEGF +405G allele may increase the risk of PCOS in South Indian women.

research Life Sciences Discovery and Technology Highlights

March 2019 in “SLAS TECHNOLOGY”

New technologies show promise in healing wounds, treating cancer, autoimmune diseases, and genetic disorders.

research The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial

306 citations , August 2011 in “Journal of cachexia, sarcopenia and muscle”

Enobosarm significantly increased muscle mass and improved physical function in elderly men and postmenopausal women without serious side effects.

research New intranasal and injectable gene therapy for healthy life extension

June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Gene therapy in mice increased lifespan and improved health without causing cancer.

research Resveratrol derivatives: a patent review (2009 – 2012)

28 citations , September 2013 in “Expert Opinion on Therapeutic Patents”

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

research Efficacy and Safety of Treatment with Combine Mycophenolate Mofetil and Corticosteroid for Lupus Nephritis:A Multicenter Open-label Study

January 2008 in “Zhonghua linchuang mianyi he biantai fanying zazhi”

The treatment with Shunyou and prednisone is effective and safe for lupus nephritis.

research Selective androgen receptor modulators: a critical appraisal

2 citations , September 2025 in “Frontiers in Endocrinology”

SARMs show promise but need more evidence to prove they're better than traditional androgens.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

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