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Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

research Chemical Mechanism of the Covalent Modification of 5.alpha.-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

12 citations , March 1995 in “Journal of the American Chemical Society”

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

research Depression common with sexual dysfunction after finasteride

August 2012 in “Reactions Weekly”

Finasteride users with sexual issues often experience depression.

research Systematic review: depression, suicidal ideation with finasteride

April 2021 in “Reactions Weekly”

Finasteride increases risk of depression, possibly suicidal thoughts, and sexual dysfunction.

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

35 citations , June 2018 in “Urology”

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

research Neurosteroid influence on affective tone

19 citations , July 2023 in “Neuroscience & Biobehavioral Reviews”

Endogenous neurosteroids may set a baseline mood.

5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

110 citations , August 2015 in “Neuropsychopharmacology”

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

research Antipsychotic-Like Properties of 5-α-Reductase Inhibitors

64 citations , March 2008 in “Neuropsychopharmacology”

research Null Mutation of 5α-Reductase Type I Gene Alters Ethanol Consumption Patterns in a Sex-Dependent Manner

11 citations , November 2014 in “Behavior Genetics”

research Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A potential contributor to Post-Finasteride Syndrome

May 2024 in “Physiology”

Finasteride may cause changes in dopamine-related genes, possibly leading to post-finasteride syndrome.

In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

research In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

14 citations , February 2011 in “Drug Metabolism and Disposition”

Ketoconazole increases finasteride's effectiveness and lifespan in the body.

Chronic Exposure of 5-Alpha Reductase Inhibitor in Young Male Rats Induces Metabolic Disturbance and Depressive-Like Behaviors

research Chronic Exposure of 5‐Alpha Reductase Inhibitor in Young Male Rats Induces Not Only Metabolic Disturbance, But Also Depressive‐Like Behaviors as Similar with Obese Condition

December 2023 in “Alzheimer's & Dementia”

Long-term use of a drug for hair loss and prostate issues can cause metabolic problems and depression-like behavior in young male rats.

research Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients

58 citations , April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology”

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

research Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids

8 citations , June 2020 in “The Journal of Clinical Endocrinology and Metabolism”

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System

1 citations , December 2021 in “Androgens”

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

research Disposition and metabolism of finasteride in dogs.

5 citations , January 1997 in “PubMed”

research Alterations in Endogenous Retinoids with Acute UVB Exposure and in the Progression of Cutaneous Squamous Cell Carcinoma

June 2015 in “OhioLink ETD Center (Ohio Library and Information Network)”

UVB exposure affects retinoid metabolism, which is important for skin cancer progression and treatment.

research Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design

12 citations , February 2023 in “Applied and Environmental Microbiology”

Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.

research Rare and common genetic determinants of metabolic individuality and their effects on human health

29 citations , November 2022 in “Nature Medicine”

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Metabolic effects of 5α-reductase inhibition in humans

July 2013 in “Edinburgh Research Archive (University of Edinburgh)”

Dutasteride may reduce insulin sensitivity and increase body fat.

Chronic Exposure With 5-Alpha Reductase Inhibitor Ameliorates Anxiety and Depression-Like Behaviors by Reducing Systemic Oxidative Stress in D-Galactose-Induced Aging Male Rats

research Chronic Exposure with 5‐Alpha Reductase Inhibitor Ameliorates Anxiety and Depression‐like Behaviors By Reducing Systemic Oxidative Stress in D‐galactose‐Induced Aging Male Rats

December 2023 in “Alzheimer's & dementia”

Finasteride may help reduce anxiety and depression in elderly but might cause depression in young men.

research Identification of xenobiotics interfering with 5 α -reductase (SRD5A2) activity

February 2026 in “Toxicology Letters”

MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.

research Drug related lipid metabolism abnormalities: a real-world pharmacovigilance exploratory analysis based on U.S. FDA adverse event reporting system (FAERS)

January 2026 in “Nutrición Hospitalaria”

Many drugs can cause lipid metabolism issues, and labels need better warnings.

Genetic Variation in CYP2B6, UGT1A4, and Sulfotransferases Is Associated with Disease-Free Survival in South African Breast Cancer Patients Treated with Tamoxifen

research Genetic Variation in CYP2B6, UGT1A4 and Sulfotransferases Is Associated with Disease-Free Survival in South African Breast Cancer Patients Treated with Tamoxifen

March 2026 in “Journal of Personalized Medicine”

Genetic differences affect breast cancer treatment success with tamoxifen in South African patients.

research Biotransformation of Finasteride (MK-0906) by Selenastrum capricornutum (Green Algae)

1 citations , December 2006 in “Annals of the New York Academy of Sciences”

Green algae can break down finasteride, reducing environmental harm.

research Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride

4 citations , July 2020 in “Research Square (Research Square)”

The research helps understand how finasteride works and aids drug development.

research New Synthesis of Finasteride

1 citations , January 2003 in “Chinese Journal of Pharmaceuticals”

A new method to make Finasteride is more cost-effective and yields 16%.

Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients

223 citations , December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

research Urinary Incontinence due to Overactive Detrusor Muscle: A Rare Side Effect of Venlafaxine

4 citations , January 2015 in “Case Reports in Urology”

Venlafaxine can cause urinary incontinence in rare cases.

research The involvement of the neurosteroid allopregnanolone in the antihyperalgesic effect of paroxetine in a rat model of neuropathic pain

11 citations , November 2011 in “Neuroreport”

Paroxetine relieves pain by increasing allopregnanolone levels.

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