Blocking 5α-reductase can reduce sleep deprivation-related behavioral issues in rats.
August 2025 in “medRxiv (Cold Spring Harbor Laboratory)” 5-alpha reductase inhibitors may increase depression risk by 31%, but results vary based on comparison groups.
January 2012 in “The Journal of Clinical Psychiatry”
27 citations
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January 2017 in “Neuropsychopharmacology” The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.
1 citations
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June 2025 in “European Journal of Clinical Pharmacology” Finasteride may increase the risk of suicidality and depression, especially in younger people.
Depressed individuals have higher hair sodium and potassium levels, similar to changes seen in astronauts.
1 citations
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June 2019 in “Current Developments in Nutrition” S-equol supplements significantly reduced menopausal symptoms in most women.
10 citations
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August 2014 in “Skin research and technology” Sleep, testosterone levels, and a specific enzyme activity affect skin oil production in women.
Finasteride may cause depression and affect brain and gut health in male rats.
Certain gene variations and different levels of BDNF and CRH hormones are linked to vitiligo.