August 2012 in “Reactions Weekly” Finasteride users with sexual issues often experience depression.
66 citations
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April 2017 in “International Journal of Andrology” Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.
October 2017 in “The Journal of Urology” 5α-Reductase inhibitors can negatively impact sexual function.
42 citations
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December 2007 in “American Journal of Psychiatry” Finasteride may effectively reduce Tourette's syndrome symptoms and improve life quality.
29 citations
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September 2014 in “Current Opinion in Endocrinology, Diabetes and Obesity” Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.
January 2005 in “Psychoneuroendocrinology” Finasteride may affect brain chemistry and behavior, offering potential for treating certain mental health conditions.
January 2018 in “ScholarWorks @UVM (University of Vermont)” Selenium in proteins helps prevent over-oxidation and supports chemical reversibility.
May 2024 in “Psychiatric News” Weight-loss drugs are not linked to suicidal thoughts.
March 2014 in “Annals of Internal Medicine” Combining α1-blockers with 5α-reductase inhibitors improves urinary symptoms in men.
37 citations
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September 2018 in “Psychoneuroendocrinology” Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
19 citations
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March 2019 in “Behavioural Brain Research” Finasteride use can cause depression-like behavior in male rats.
1 citations
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November 2021 in “British Journal of Clinical Pharmacology” Saw palmetto may cause erectile dysfunction and needs better safety monitoring.
July 2025 in “American Journal on Addictions” Using 5-alpha reductase inhibitors may lower the risk of opioid addiction in men taking opioids.
91 citations
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July 2004 in “Journal of Biological Chemistry” Overexpressing SSAT enzyme reduces prostate tumor growth in mice.
July 2025 in “Reactions Weekly” April 2023 in “European urology open science” Urologists should screen for mental health issues before and during finasteride treatment.
October 2010 in “Journal of Men's Health” Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.
2 citations
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October 2002 in “American Journal of Nursing” Taking the same medication under different brand names caused harmful side effects.
6 citations
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September 2016 in “Journal of Mind and Medical Sciences” Finasteride can cause side effects, some lasting after treatment ends, and may lead to severe depression or suicidal thoughts.
Finasteride may cause depression and affect brain and gut health in male rats.
April 2026 in “Brain Sciences” Finasteride may cause depression and suicidal thoughts, especially in young men.
January 2012 in “The Journal of Clinical Psychiatry” March 2005 in “European Urology Supplements” December 2013 in “The Journal of Urology” 4 citations
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July 2020 in “Research Square (Research Square)” The research helps understand how finasteride works and aids drug development.
63 citations
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March 1998 in “Archives of Dermatology” Antidepressants may improve or resolve scalp dysesthesia in most patients.
49 citations
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January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.
April 2011 in “Reactions Weekly”
January 2024 in “Saudi pharmaceutical journal” The study successfully formulated and optimized a bilayer tablet combining Tamsulosin and Finasteride using response surface methodology.