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Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

Women with PCOS and polycystic ovaries have higher male hormone levels and more insulin resistance, especially if they are overweight.

Aldactone was more effective in reducing hair growth in women with hirsutism than Diane, despite having less impact on hormone levels.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.