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The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Retinoic acid production and signaling in hair follicles are regulated by location and timing, affecting hair growth and cycling.

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

Human skin can make serotonin and melatonin.

A form of vitamin E promotes hair growth by activating a specific skin pathway.

The research identified unique metabolic activities in immune cells associated with hair loss in Alopecia Areata.

The Shindai method effectively extracts keratin from human hair, with potential uses in bioplastics and biofertilizers.

A gene called Gk5 controls lipid production in the skin and affects hair growth.

The enzyme Dgat1 is essential for healthy hair and skin by controlling retinoid levels.

Stephania longa's genome helps understand how it makes the alkaloid cepharanthine.

A new method using 1,4-n-butylene dimaleate effectively repairs and strengthens damaged hair.

A new perming method is less damaging to hair and works as well as traditional methods.

Nitrogen starvation in microalgae increases lipid production, making it a potential biofuel source.

Auxin pathways help maintain balance in plant growth and development.

New method makes important drug ingredients more easily without needing extra purification steps.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Disrupted citric acid metabolism stops hair growth.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

Both SMS1 and SMS2 are crucial for normal hair growth and cycle in mice.

Early diagnosis and proper treatment improve outcomes for methylmalonic acidemia.

Human skin cells have a high-affinity system for biotin transport, crucial for skin health.

DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.

JAK/STAT1 pathway causes hair loss during chemotherapy by reducing Shh in hair follicles.

Hair growth pathways are a promising and simpler method for detecting chronic stress.

The study identified a key protein involved in producing underarm odor and found ways to inhibit it.

Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.