research Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy
Older skin has higher cancer risk due to inflammation and stem cell issues.
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research A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma
Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.
research Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine
Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.
research Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Controlled light treatment in mouse skin speeds up healing and hair growth.
research Dusko Ilic† explores the latest developments in the field of stem cell research and regenerative medicine
Stem cell research and regenerative medicine have made significant advancements in treating various diseases and conditions.
research Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments
Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.
research Stem cell plasticity enables hair regeneration following Lgr5+ cell loss
Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
research Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS
Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.
research Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate
Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.
research An Investigation of Hair and its Keratin Associated Proteins using Advanced Light Microscopy
Advanced microscopy shows hair damage and keratin proteins' roles, aiding future cosmetic treatments.
research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Fat-related cells are important for initiating hair growth.
research Skin Cell Heterogeneity in Development, Wound Healing, and Cancer
Different types of skin cells play specific roles in development, healing, and cancer.
research What does the concept of the stem cell niche really mean today?
Stem cell niches support, regulate, and coordinate stem cell functions.
research Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche
Different types of stem cells and their environments are key to skin repair and maintenance.
research Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway
LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.
research Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny
The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.
research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate
The extracellular matrix is crucial for controlling skin stem cell behavior and health.
research Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure
Researchers created rat liver stem cells that could help repair liver failure in rats and may be useful for studying human liver diseases.
research From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots
The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.
research Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract
Blocking enzymes that help the virus enter cells could be a promising way to treat COVID-19.
research A Spontaneous Deletion within the Desmoglein 3 Extracellular Domain of Mice Results in Hypomorphic Protein Expression, Immunodeficiency, and a Wasting Disease Phenotype
A gene deletion in mice causes weak protein, immune issues, hair loss, airway problems, and wasting disease.
research The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances
BAFF-targeted therapies can reduce autoimmune disease activity, but more research is needed for precise treatments.
research A Review of the Impact of Calorie Restriction on Stem Cell Potency
Eating fewer calories improves the ability of stem cells to repair and renew the body in various tissues.
research Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation
Increasing Smurf2 hinders hair follicle stem cell differentiation and wound healing.
research Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea
Increasing Rps14 helps grow more inner ear cells and repair hearing cells in baby mice.
research Establishment and Functional Characterization of Immortalized Rabbit Dermal Papilla Cell Lines
Researchers created a stable rabbit cell line for hair research that doesn't age quickly or become cancerous.
research Stem Cell: Current and Future State
Stem cells show promise for hair loss treatment, but no effective product for hair regeneration has been developed yet.
research Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle
Ephrins slow down skin and hair follicle cell growth.
research Multi-potentiality of a new immortalized epithelial stem cell line derived from human hair follicles
Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
research Cleave but not leave: Astrotactin proteins in development and disease
Astrotactin proteins are important for brain and skin development and are linked to several neurodevelopmental disorders.