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GlossarySkin Glands

specialized structures in skin producing sebum and sweat

Skin glands are specialized structures within the skin that produce and secrete various substances. The two main types are sebaceous glands, which secrete an oily substance called sebum to lubricate and protect the skin and hair, and sweat glands, which help regulate body temperature and excrete waste products through perspiration. These glands play crucial roles in maintaining skin health and homeostasis.

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research Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors

44 citations , July 2016 in “Stem Cells Translational Medicine”

Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.

research The Morphological Basis of vicuña wool: Skin and gland structure in Vicugna vicugna (Molina 1782)

4 citations , March 2016 in “Small ruminant research”

Vicuña wool's quality is due to a high density of fine secondary hair follicles, and their skin glands may be used for communication.

research Pmg-1 and Pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development

22 citations , August 1999 in “Mechanisms of Development”

Pmg-1 and Pmg-2 are new genes important for skin and mammary gland development.

Sericin Hydrogels Promote Skin Wound Healing with Effective Regeneration of Hair Follicles and Sebaceous Glands After Complete Loss of Epidermis and Dermis

research Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis

84 citations , January 2018 in “Biomaterials Science”

Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.

research GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing

19 citations , January 2015 in “Scientific Reports”

GPR39 is linked to certain cells in the sebaceous gland and helps with skin healing.

research Sebaceous Gland Regeneration in Human Skin Xenografts

9 citations , May 2010 in “Journal of Investigative Dermatology”

Human sebaceous glands can grow back in skin grafts on mice and work like normal human glands.

Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

research Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

6 citations , August 2014 in “Toxicologic pathology”

Blocking DGAT1 reduces oil gland size in mice and dogs, but only mice experience hair loss.

research Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland

2 citations , May 2023 in “Frontiers in Pharmacology”

Natural products may help treat skin inflammation from abnormal adrenal hormones.

research 1350 Human scalp skin as an abundant and accessible source for eccrine sweat gland isolation and organ culture

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers found a new way to isolate sweat glands from the scalp for study and culture.

Sweat Glands Shrink Upward With Aging, Causing Dermal Layer Defects Leading to Loss of Skin Elasticity and Wrinkling - Establishment of 3D Imaging Method for Skin Appendages

research 250 Sweat glands shrink upward with aging, causing dermal layer defects that lead to loss of skin elasticity and wrinkling-establishment of 3D imaging method for skin appendages

September 2017 in “Journal of Investigative Dermatology”

Aging causes sweat glands to shrink and move upward, leading to less elastic skin and more wrinkles.

research 1115 Interrogating the gut-skin axis for acne and sebaceous gland health – a case study of nicotinic acid

April 2023 in “Journal of Investigative Dermatology”

Taking nicotinic acid supplements might help with acne by affecting the skin's oil glands, but high doses are needed.

research Glandular metaplasia of hair follicles and other responses to vitamin A excess in cultures of rodent skin

77 citations , April 1968 in “Development”

Excess vitamin A can cause hair follicles to change into gland-like structures.

research Retinoic Acid and Mouse Skin Morphogenesis. II. Role of Epidermal Competence in Hair Glandular Metaplasia

16 citations , November 1994 in “Developmental Biology”

Retinoic acid causes gland formation instead of hair in mouse skin by altering epidermal and dermal interactions.

research Differential distribution and genetic determination of eccrine sweat glands and hair follicles in the volar skin of C57BL/6 mice and SD rats

8 citations , August 2022 in “BMC Veterinary Research”

C57BL/6 mice and SD rats have different sweat gland and hair follicle patterns, useful for skin research.

research Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

October 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Musk glands and skin in Chinese forest musk deer are closely related and share many genes.

research 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion?

November 2022 in “Journal of Investigative Dermatology”

Deleting MPZL3 increases skin oil production and reduces body fat.

research Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris

December 2022 in “Research Square (Research Square)”

Isotretinoin treatment increases p53 levels in the skin, which may explain its effectiveness against acne.

research Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris

May 2022 in “Research Square (Research Square)”

Isotretinoin treatment increases p53 levels in the skin, which may explain its effectiveness against acne.

research Neuroimmunoregulation of Androgens in the Adrenal Gland and the Skin

48 citations , January 2000 in “Hormone Research in Paediatrics”

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Overexpression of Cyclooxygenase-2 in the Skin of Adult Transgenic Mice Leads to Sebaceous Gland Hyperplasia and Thinning of Hair Shafts

research 919 Overexpression of cyclooxygenase-2 in the skin of adult transgenic mice leads to sebaceous gland hyperplasia and thinning of hair shafts

April 2019 in “Journal of Investigative Dermatology”

Increasing COX-2 in mouse skin causes bigger sebaceous glands and thinner hair, but stopping COX-2 can reverse hair thinning.

research Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin

11 citations , August 2000 in “Journal of Endocrinology”

DHEA acts like a male hormone on rat skin glands and doesn't turn into female hormones there.

research Isolated Human Skin Glands and Appendages: Models for Cystic Fibrosis, Acne Vulgaris, Alopecia and Hidradenitis Suppurativa

January 1990

research Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris

1 citations , December 2022 in “Archives of Dermatological Research”

Acne treatment with isotretinoin increases the presence of p53, a protein, in skin and oil glands, which may help reduce acne severity.

Isolation and Characterization of Sweat Gland Myoepithelial Cells from Human Skin

research The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin

8 citations , January 2013 in “genesis”

Zfp157 is active in many mouse tissues during development and in specific adult cells.

research Retinoic Acid and Mouse Skin Morphogenesis. I. Expression Pattern of Retinoic Acid Receptor Genes During Hair Vibrissa Follicle, Plantar, and Nasal Gland Development

24 citations , July 1994 in “Journal of Investigative Dermatology”

research Both Retinoic Acid Receptors α (RARα) and γ (RARγ) Are Able to Initiate Mouse Upper-Lip Skin Glandular Metaplasia

10 citations , August 1998 in “Journal of Investigative Dermatology”

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Related Terms

Research

research Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors

research The Morphological Basis of vicuña wool: Skin and gland structure in Vicugna vicugna (Molina 1782)

research Pmg-1 and Pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development

research Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

research GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing

research Sebaceous Gland Regeneration in Human Skin Xenografts

research Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

research Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland

research 1350 Human scalp skin as an abundant and accessible source for eccrine sweat gland isolation and organ culture

research 250 Sweat glands shrink upward with aging, causing dermal layer defects that lead to loss of skin elasticity and wrinkling-establishment of 3D imaging method for skin appendages

research 1115 Interrogating the gut-skin axis for acne and sebaceous gland health – a case study of nicotinic acid

research Glandular metaplasia of hair follicles and other responses to vitamin A excess in cultures of rodent skin

research Retinoic Acid and Mouse Skin Morphogenesis. II. Role of Epidermal Competence in Hair Glandular Metaplasia

research Differential distribution and genetic determination of eccrine sweat glands and hair follicles in the volar skin of C57BL/6 mice and SD rats

research Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

research 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion?

research Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris

research Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris

research Neuroimmunoregulation of Androgens in the Adrenal Gland and the Skin

research 919 Overexpression of cyclooxygenase-2 in the skin of adult transgenic mice leads to sebaceous gland hyperplasia and thinning of hair shafts

research Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin

research Isolated Human Skin Glands and Appendages: Models for Cystic Fibrosis, Acne Vulgaris, Alopecia and Hidradenitis Suppurativa

research Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris

research Isolation and Characterization of Sweat Gland Myoepithelial Cells from Human Skin

research The human skin as a hormone target and an endocrine gland

research Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin

research The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin

research Retinoic Acid and Mouse Skin Morphogenesis. I. Expression Pattern of Retinoic Acid Receptor Genes During Hair Vibrissa Follicle, Plantar, and Nasal Gland Development

research Both Retinoic Acid Receptors α (RARα) and γ (RARγ) Are Able to Initiate Mouse Upper-Lip Skin Glandular Metaplasia