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GlossaryHyperkeratosis

excessive thickening of skin's outer layer due to keratin

Hyperkeratosis is a condition where the outer layer of the skin, known as the stratum corneum, becomes excessively thick due to an overproduction of keratin. This can result in rough, scaly patches on the skin and is often seen in conditions like psoriasis or eczema. For professionals, it is important to note that hyperkeratosis can be a response to chronic irritation or inflammation and may require targeted treatments to manage the underlying cause.

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research Intracorneal vacuoles in skin diseases with parakeratotic hyperkeratosis in the dog: a retrospective light‐microscopy study of 111 cases (1973–2000)

7 citations , February 2002 in “Veterinary Dermatology”

Intracorneal vacuoles are common in parakeratotic skin diseases in dogs, especially with more parakeratosis.

research Obesity and the skin

128 citations , September 2011 in “British Journal of Dermatology”

Obesity is linked to various skin problems and may increase the risk of skin cancer.

research RASopathic Skin Eruptions during Vemurafenib Therapy

82 citations , March 2013 in “PLoS ONE”

Vemurafenib causes skin side effects similar to RASopathies, requiring regular skin checks and UVA protection.

research Skin manifestations of obesity: a comparative study

45 citations , September 2011 in “Journal of the European Academy of Dermatology and Venereology”

Obese people have more skin problems like stretch marks and infections, which get worse with higher obesity levels.

research Antigen presenting cells in the skin of a patient with hair loss and systemic lupus erythematosus.

9 citations , September 2009 in “PubMed”

Antigen presenting cells around hair follicles are crucial in SLE-related hair loss.

research Skin features in myotonic dystrophy type 1: An observational study

8 citations , March 2015 in “Neuromuscular Disorders”

People with Myotonic Dystrophy type 1 are more likely to have certain skin conditions, but not more likely to get skin cancer.

research Bacteria and fungi on the surface and within noninflamed hair follicles of skin biopsy specimens from horses with healthy skin or inflammatory dermatoses

7 citations , February 2005 in “Veterinary Dermatology”

Horses with skin disease have more surface bacteria than healthy horses.

research Correction: RASopathic Skin Eruptions during Vemurafenib Therapy

4 citations , October 2013 in “PLoS ONE”

Vemurafenib causes significant skin side effects, requiring regular dermatologist care and sun protection.

research Unilateral nevoid hyperkeratosis of the nipple and areola in a Saudi female

2 citations , July 2018 in “Our Dermatology Online”

Calcipotriol cream reduced skin thickening and itching in a rare nipple condition.

research A Rare Case of Orthokeratotic Hyperkeratosis in a Kid Induced by Malassezial Dermatitis

January 2024 in “The Indian Veterinary Journal”

A young goat with skin issues improved with medication and supplements.

research Skin manifestations and biophysical changes following weight reduction induced by bariatric surgery: A 2‐year prospective study

September 2023 in “The Journal of Dermatology”

Bariatric surgery improved many skin conditions in obese patients but caused hair loss in some and decreased facial oil and skin elasticity.

Skin Manifestations and Biophysical Properties in Patients With Morbid Obesity and Changes After Weight Loss: A Two-Year Prospective Study

research 393 Skin manifestations and biophysical properties in patients with morbid obesity and changes after weight loss: A two-year prospective study

April 2023 in “Journal of Investigative Dermatology”

Weight loss surgery improved several skin conditions in obese patients but often caused hair loss.

research Case Report: Bi-allelic missense variant in the desmocollin 3 gene causes hypotrichosis and recurrent skin vesicles

August 2022 in “Frontiers in genetics”

A new genetic change in the DSC3 gene is linked to a rare condition causing hair loss and skin blisters in a child.

research Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

16 citations , June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.

research Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis

15 citations , February 2020 in “Journal of Investigative Dermatology”

Ceramide Synthase 4 is crucial for healthy skin barrier function.

research Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice

81 citations , February 2014 in “EMBO molecular medicine”

Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.

research Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function

74 citations , June 2018 in “Cell death and disease”

Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.

research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

54 citations , December 2011 in “American Journal Of Pathology”

A Gsdma3 mutation causes hair loss due to stem cell damage from skin inflammation.

research Lesions in the skin, intestine, and central nervous system induced by an antimetabolite of niacin.

12 citations , February 1986 in “PubMed”

Injecting newborn mice with a niacin blocker caused skin, gut, and brain damage similar to human pellagra.

research Immunohistochemical Expression of Keratins in Normal Ovine Skin and in Chronic Dermatitis due to Sarcoptes scabiei

2 citations , February 2021 in “Journal of comparative pathology”

Sheep with chronic Sarcoptes scabiei dermatitis have altered keratin expression in their skin.

research Skin Lesions in a Daclizumab-treated Patient with Multiple Sclerosis

1 citations , March 2019 in “Journal of Interdisciplinary Medicine”

A patient with multiple sclerosis developed skin reactions after Daclizumab treatment, requiring more data on the drug's effects.

research Epidermis-specific ablation of claudin-1 in adult mice demonstrates the essential role of a tight junction barrier in skin homeostasis

1 citations , September 2016 in “Journal of Dermatological Science”

Claudin-1 is crucial for maintaining skin barrier and preventing inflammation.

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

January 2025 in “International Journal of Molecular Sciences”

Non-liganded Vitamin D Receptor is crucial for healthy skin and hair.

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

November 2024

Vitamin D receptor actions without binding are crucial for healthy skin and hair.

Skin Barrier, Phenotypic and Genotypic Characterization of Autosomal Recessive Ichthyosis in TGM1-Deficient Jack Russell Terriers and Response to Topical Ceramide

research Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1‐deficient Jack Russell Terriers and response to topical ceramide

August 2024 in “Veterinary Dermatology”

Topical ceramide treatment partially improves the skin condition in Jack Russell Terriers with a genetic skin disorder.

Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

research 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

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Related Terms

Research

research Intracorneal vacuoles in skin diseases with parakeratotic hyperkeratosis in the dog: a retrospective light‐microscopy study of 111 cases (1973–2000)

research Obesity and the skin

research RASopathic Skin Eruptions during Vemurafenib Therapy

research Skin manifestations of obesity: a comparative study

research Antigen presenting cells in the skin of a patient with hair loss and systemic lupus erythematosus.

research Skin features in myotonic dystrophy type 1: An observational study

research Bacteria and fungi on the surface and within noninflamed hair follicles of skin biopsy specimens from horses with healthy skin or inflammatory dermatoses

research Correction: RASopathic Skin Eruptions during Vemurafenib Therapy

research Unilateral nevoid hyperkeratosis of the nipple and areola in a Saudi female

research A Rare Case of Orthokeratotic Hyperkeratosis in a Kid Induced by Malassezial Dermatitis

research Skin manifestations and biophysical changes following weight reduction induced by bariatric surgery: A 2‐year prospective study

research 393 Skin manifestations and biophysical properties in patients with morbid obesity and changes after weight loss: A two-year prospective study

research Case Report: Bi-allelic missense variant in the desmocollin 3 gene causes hypotrichosis and recurrent skin vesicles

research Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

research Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis

research Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice

research Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function

research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

research Lesions in the skin, intestine, and central nervous system induced by an antimetabolite of niacin.

research Immunohistochemical Expression of Keratins in Normal Ovine Skin and in Chronic Dermatitis due to Sarcoptes scabiei

research Skin Lesions in a Daclizumab-treated Patient with Multiple Sclerosis

research Epidermis-specific ablation of claudin-1 in adult mice demonstrates the essential role of a tight junction barrier in skin homeostasis

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

research Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1‐deficient Jack Russell Terriers and response to topical ceramide

research 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis

research Respective Treatment Modalities with the Use of Combined Ingredients to Address Acne Prone Skin

research Skin, Genetic Defects, and Aging

research The Roles of Smad2 and Smad3 in Mouse Skin Development

research Cutaneous Ultrastructural Features of the Flaky Skin (fsn) Mouse Mutation