research The immunology of the porcine skin and its value as a model for human skin
Porcine skin is very similar to human skin, making it a useful model for research.
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research Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models
Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.
research Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls
Hair growth environment recreated with challenges; stem cells make successful skin organoids.
research Experimental cutaneous Bacillus anthracis infections in hairless HRS/J mice
Hairless HRS/J mice resist Bacillus anthracis skin infections due to high numbers of immune cells, not because they lack hair follicles.
research Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration
Different stem cells are key for hair growth and health, and understanding their regulation could help treat hair loss.
research Immunopathogenesis of Primary Cicatricial Alopecia
Hair loss in Lichen Planopilaris is caused by immune system issues damaging hair follicles and stem cells.
research Defining dermal adipose tissue
Skin fat cells help with skin balance, hair growth, and healing wounds.
research Skinny Fat Cells Stimulate Wound Healing
Skinny fat cells help wounds heal faster by releasing fatty acids.
research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice
The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.
research Ox40-Cre–mediated deletion of BRD4 reveals an unexpected phenotype of hair follicle stem cells in alopecia
Deleting the BRD4 protein in certain skin cells causes hair loss and skin inflammation.
research Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration
Bead-jet printing of stem cells improves muscle and hair regeneration.
research β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.
research Epidermal stem cells in wound healing and their clinical applications
Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
research Beyond acne: Current aspects of sebaceous gland biology and function
The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.
research Wnt signaling induces epithelial differentiation during cutaneous wound healing
Wnt signaling is crucial for skin wound healing and reducing scars.
research Prolactin: an emerging force along the cutaneous–endocrine axis
Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.
research Eph/ephrin signaling in epidermal differentiation and disease
Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.
research Concise Review: Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine
Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
research Regulatory T cells in dominant immunologic tolerance
Regulatory T cells help prevent autoimmunity and have potential for treating autoimmune diseases.
research Stem Cell Therapy for Burns: Story so Far
Stem cell therapy shows promise in improving burn wound healing.
research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin
Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.
research Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation
Human skin xenografting could improve our understanding of skin development, renewal, and healing.
research Fondation René Touraine
The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.
research CD169+ Skin Macrophages Function as a Specialized Subpopulation in Promoting Psoriasis-like Skin Disease in Mice
Targeting CD169+ skin macrophages may help treat psoriasis.
research Transient skin stretching stimulates immune surveillance and promotes vaccine delivery via hair follicles
Skin stretching can improve vaccine delivery through hair follicles and boost immune response.
research Editors' Picks
Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.
research Apoptosis and cutaneous biology
Apoptosis is crucial for healthy skin and treating skin diseases.
research Macrophage ferroportin is essential for stromal cell proliferation in wound healing
Macrophage iron release is crucial for hair growth and wound healing.
research Multipotent Nestin-Positive Stem Cells Reside in the Stroma of Human Eccrine and Apocrine Sweat Glands and Can Be Propagated Robustly In Vitro
Human sweat glands have a type of stem cell that can grow well and turn into different cell types.
research Inherited epidermolysis bullosa: clinical and therapeutic aspects
The document concludes that inherited epidermolysis bullosa is a challenging genetic condition requiring multidisciplinary care and new treatments.