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GlossaryBasal Cell Carcinoma

most common skin cancer, originating in basal epidermal cells

Basal Cell Carcinoma (BCC) is the most common type of skin cancer, originating in the basal cells, which are found in the deepest layer of the epidermis. It typically appears as a small, shiny bump or nodule on sun-exposed areas of the skin, such as the face and neck, and is usually caused by long-term exposure to ultraviolet (UV) radiation from the sun or tanning beds. While BCC rarely metastasizes, it can cause significant local damage if not treated promptly.

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research Identical p53 gene mutation in malignant proliferating trichilemmal tumour of the scalp and small cell carcinoma of the common bile duct: the necessity for therapeutic caution?

11 citations , May 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

Identical p53 gene mutations in different cancers suggest the need for careful treatment.

Novel Small Molecules Downregulate CDK1 Expression and Inhibit Wnt/β-Catenin Signaling in Cutaneous Squamous Cell Carcinoma by Targeting Its Distinct Tumor-Specific Cellular Landscape

research Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape

September 2025 in “Experimental & Molecular Medicine”

Small molecules KY19382 and KY19334 may help treat skin cancer by reducing CDK1 levels and blocking harmful cell signals.

research Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma

87 citations , January 1999 in “British Journal of Dermatology”

Trichoblastic fibroma and basal cell carcinoma are similar but different from trichoepithelioma.

research Non-small cell lung carcinoma spheroid models in agarose microwells for drug response studies

45 citations , January 2022 in “Lab on a Chip”

The platform effectively grows lung cancer cell spheroids for drug testing.

research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

63 citations , May 2011 in “Clinical cancer research”

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

research Data from Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

March 2023

The treatment was ineffective in humans.

Proliferation, But Not Apoptosis, Is Associated With Distinct Beta-Catenin Expression Patterns in Non-Small-Cell Lung Carcinomas

research Proliferation, but Not Apoptosis, Is Associated with Distinct β-Catenin Expression Patterns in Non-Small-Cell Lung Carcinomas

42 citations , November 2002 in “The American journal of pathology”

Distinct β-catenin patterns are linked to cell growth, not cell death, in lung cancer.

research AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

60 citations , October 2020 in “Nature Communications”

AP-1 and TGFß work together to drive resistance in basal cell carcinoma, suggesting new treatment options.

research A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy

105 citations , October 2018 in “Nature”

A small group of slow-growing cells causes basal cell carcinoma to return after treatment.

research Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease

14 citations , May 2022 in “Cell Reports”

Basal cell carcinomas need extra mutations to grow from small to large tumors.

research The skin as a window on internal disorders: Two cases of internal malignancy and hypervitaminosis B12

October 2020 in “Our Dermatology Online”

Skin changes and high vitamin B12 levels can be early signs of cancer.

Advancements and Challenges in Hair Transplantation Surgery

research Hair Transplantation

2 citations , August 1994 in “The Journal of Dermatologic Surgery and Oncology”

The article concludes that hair transplantation is advancing, but a reliable way to ensure complete tumor removal is still needed.

Characteristics of KRT80 and Its Roles in Neoplastic Diseases

research Characters of KRT80 and its roles in neoplasms diseases

2 citations , May 2023 in “Cancer medicine”

KRT80 may worsen cancer by increasing growth and spread, but its full effects on treatment and outcomes need more research.

research CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle.

17 citations , January 2010 in “PubMed”

CD10 helps distinguish between basal cell carcinoma and benign hair follicle tumors.

research Near missed diagnosis of Merkel Cell Carcinoma in a young immunocompetent woman with a recurrent left-arm mass: A case report

April 2023 in “Authorea (Authorea)”

A young woman with a rare skin cancer was diagnosed late because her symptoms were unusual for the disease.

research Utility of GLI1 RNA Chromogenic in Situ Hybridization in Distinguishing Basal Cell Carcinoma From Histopathologic Mimics

3 citations , June 2023 in “Modern Pathology”

GLI1 RNA CISH effectively identifies basal cell carcinoma but is less specific for benign follicular tumors.

research Hair sheath keratins in follicular tumors. (5). Identification of hair sheath keratins in keratoacanthoma; Histopathological hair sheath structures in the tumor and their significance as differential histopathological criteria from squamous cell carcinoma.

January 1990 in “The Nishinihon Journal of Dermatology”

Follicular structures help differentiate keratoacanthoma from squamous cell carcinoma.

research Efficacy of albumin-bound paclitaxel combined with nedaplatin in neoadjuvant therapy for esophageal squamous cell carcinoma: A single-center retrospective observational study

1 citations , March 2023 in “Medicine”

The combination therapy is effective and well-tolerated for treating esophageal cancer.

research A case of trichogerminoma: a rare cutaneous follicular neoplasm

December 2021 in “Pathologica”

Trichogerminoma is a rare, benign skin tumor from hair cells, with a small risk of becoming cancerous.

research Trichoblastic Carcinoma

2 citations , July 2001 in “Dermatologic Surgery”

Trichoblastic carcinoma may be a distinct type of skin cancer different from basal cell carcinoma.

research Functional analysis of collagen XVII in epithelial cancers and a mouse model

January 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Collagen XVII is important for cell functions and its absence can worsen cancer outcomes.

research DP18 A mimicker of melanoma on sun-exposed sites

June 2025 in “British Journal of Dermatology”

Melanocytic matricoma can look like skin cancer but is usually harmless; surgery and follow-up are advised.

Persistent Wound Healing Disorders After Local Therapy of Scalp Field Cancerization with Imiquimod or Diclofenac

research Persistierende Wundheilungsstörungen nach Lokaltherapie von Feldkanzerisierung des Capillitiums mit Imiquimod oder Diclofenac

October 2014 in “Aktuelle Dermatologie”

Older men with scalp wounds had long-term healing problems after using imiquimod or diclofenac for skin cancer prevention.

research Control by a hair’s breadth: the role of microRNAs in the skin

41 citations , September 2012 in “Cellular and Molecular Life Sciences”

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

research Exploiting the origins of Ras mediated squamous cell carcinoma to develop novel therapeutic interventions

3 citations , November 2011 in “Small GTPases”

Researchers found that hair follicle stem cells can become squamous cell carcinoma due to Ras activation, which could lead to new treatments.

research Highlights

September 2016 in “JAMA Dermatology”

Melanoma patients can learn to check their skin, early balding in men may indicate similar risks as PCOS in women, certain criteria can help predict skin cancer behavior, small skin cancer may not need extra therapy after surgery, and sterile gloves don't reduce infection in minor surgeries.

research The metabolism of testosterone by dermal papilla cells cultured from scalp follicles of men with androgenetic alopecia

August 1993 in “Journal of Dermatological Science”

Testosterone metabolism in balding scalp cells may not be the main cause of hair loss.

research Epidermal growth factor receptor inhibitor Geftinib-induced erosive pustular dermatosis of the scalp – A report with a brief review of the literature

November 2023 in “Journal of Skin and Sexually Transmitted Diseases”

Gefitinib can cause scalp skin issues and permanent hair loss.

research Prodrugs of butyric acid from bench to bedside: Synthetic design, mechanisms of action, and clinical applications

70 citations , January 2000 in “Drug Development Research”

New butyric acid prodrugs show promise for cancer treatment, anemia management, and protecting hair from chemotherapy damage.

research Case 5

May 2019 in “Small Animal Dermatology”

The cat had a rare condition linked to cancer, leading to its euthanasia.